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DiaMedBase
ID
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DMPCs133 |
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Medicinal
Plant |
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Camellia sinensis (Green
Tea) |
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Plant part(s)
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Leaves |
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Objective |
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To study the the major green
tea polyphenolic constituent, epigallocatechin 3-gallate (EGCG) |
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Journal
Source |
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Planta Med.
2004; 70(11):1100-1102 |
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Title
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Effects of green tea on gene
expression of hepatic gluconeogenic enzymes in vivo |
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Authors
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Koyama Y, Abe K, Sano Y,
Ishizaki Y, Njelekela M, Shoji Y, Hara Y, Isemura M |
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Address
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Laboratory of Cellular
Biochemistry, COE Program in the 21st Century, Graduate School of
Nutritional and Environmental Sciences, The University of Shizuoka,
Shizuoka, Japan |
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Abstract
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It has recently been reported
that the major green tea polyphenolic constituent, epigallocatechin
3-gallate (EGCG), mimics the cellular effects of insulin including the
reductive effect on the gene expression of rate-limiting gluconeogenic
enzymes in a cell culture system. We show that administration of green
tea that contains EGCG caused a reduction in the level of mRNAs for
gluconeogenic enzymes, phosphoenolpyruvate carboxykinase and
glucose-6-phosphatase in the mouse liver. EGCG alone was also found to
down-regulate the gene expression of these enzymes but not so curcumin
or quercetin. The results of this study support the idea that green
tea intake may be beneficial in the prevention of diabetes mellitus. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCs134 |
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Medicinal Plant
|
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Camellia sinensis |
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Plant part(s)
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|
Leaves |
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Objective |
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To
study the effects of long-term (up to 16 weeks)
administration of green tea preparations on body weight, blood sugar
and lipid content |
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Journal Source
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Journal of Food Biochemistry
2005; 29(3):295-304 |
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Title
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Effects of Long-Term Oral Administration of Green Tea Cultivated in
Different Districts in Japan On Body Weight, Blood Lipid and Glucose
Levels on db/db mice |
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Authors
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Kayoko Maeda1*,
Takeo Hasegawa1, Kousuke Murabayashi1, Atushi
Fukuyama1 And Michihiro Ohya2 |
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Address
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1Graduate
School of Health Science, Suzuka University of Medical Science,
Kisiokacho 1001-1 Suzuka, 510-0293, Japan 2West
Hospital Kobe, Nagataku Ichibancho 2-4 Kobe, 653-0013, Japan |
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Abstract
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Previous research using
short-term animal experiments has indicated that oral administration
of green tea can suppress elevation of blood sugar. However, few data
are available on the antihyperglycemia effect of green tea in
long-term experiments. In this study, effects of long-term (up to 16
weeks) administration of green tea preparations on body weight, blood
sugar and lipid content of db/db and db/+m mice were examined.
Preparations were prepared by the same procedure from tea leaves
cultivated in different districts in Japan. Significant differences (P
< 0.05) were observed in the blood parameters and body weight between
control and green tea groups of db/db mice. In the case of normal
mice, however, no significant difference was observed. In addition,
the response to the administration of green tea depended on the source
and composition of tea leaves. |
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Diseases |
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Disease Link |
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DiaMedBase
ID |
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DMPCs135 |
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Medicinal
Plant |
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Cinnamomun zeylanicum,
Hamamelis virginiana (witchhazel),
Camellia
sinensis (green
and black teas),
Pimenta dioica (allspice),
Laurus
nobilis L. (bay
leaves),
Myristica fragrens (nutmeg),
Syzgium
aromaticum (cloves),
mushrooms, and brewer's yeast |
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Plant part(s)
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Whole plant |
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Objective |
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To
evaluate the possible effects on insulin function |
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Journal
Source |
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J Agric Food Chem,
2000;
48(3):849-852 |
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Title
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Insulin-like biological activity of
culinary and medicinal plant aqueous extracts in vitro |
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Authors
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Broadhurst
CL, Polansky MM, Anderson RA |
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Address
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Nutrient Requirements and Functions
Laboratory, Beltsville Human Nutrition Research Center, Agricultural
Research Service, U.S. Department of Agriculture, Beltsville, Maryland
20705-2350, USA |
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Abstract
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To evaluate the possible effects on
insulin function, 49 herb, spice, and medicinal plant extracts were
tested in the insulin-dependent utilization of glucose using a rat
epididymal adipocyte assay. Cinnamon was the most bioactive product
followed by witch hazel, green and black teas, allspice, bay leaves,
nutmeg, cloves, mushrooms, and brewer's yeast. The glucose oxidation
enhancing bioactivity was lost from cinnamon, tea, witchhazel, cloves,
bay leaf and allspice by poly(vinylpyrrolidone) (PVP) treatment,
indicating that the active phytochemicals are likely to be phenolic in
nature. The activity of sage, mushrooms, and brewers's yeast was not
removed by PVP. Some products such as Korean ginseng, flaxseed meal,
and basil have been reported to be effective antidiabetic agents;
however, they were only marginally active in our assay. Our technique
measures direct stimulation of cellular glucose metabolism, so it may
be that the active phytochemicals in these plants improve glucose
metabolism via other mechanisms or that this in vitro screening is not
a reliable predictor of hypoglycemic effects in vivo for some
products. In summary, the positive effects of specific plant extracts
on insulin activity suggest a possible role of these plants in
improving glucose and insulin metabolism. |
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Diseases |
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Disease Link |
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