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DiaMedBase ID |
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DMPCc141 |
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Medicinal Plant
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Carum carvi
and Capparis spinosa |
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Plant part(s)
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Fruits |
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Objective |
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To study the hypoglycaemic
effect of fruit aqueous extracts of Carum carvi (CC) and Capparis
spinosa L. (CS) in normal and streptozotocin diabetic rats |
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Journal Source
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J Ethnopharmacol.
2004; 94(1):143-148 |
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Title
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Caraway and caper:
potential anti-hyperglycaemic plants in diabetic rats |
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Authors
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Eddouks M, Lemhadri A,
Michel JB |
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Address
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Laboratory of Endocrinian
Physiology, FSTE Boutalamine and Pharmacology, EDDOUKS, UFR PNPE, BP
21, Errachidia 52000, Morocco. m.eddouks@caramail.com |
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Abstract
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The hypoglycaemic effect
of aqueous extracts of Carum carvi (CC) and Capparis spinosa L. (CS)
fruit were investigated in normal and streptozotocin (STZ) diabetic
rats. After a single dose or 14 daily doses, oral administration of
the aqueous CC and CS extracts (20 mg/kg) produced a significant
decrease on blood glucose levels in STZ diabetic rats (P < 0.001); the
blood glucose levels were nearly normalised 2 weeks after daily
repeated oral administration of both aqueous CC and CS extracts (20
mg/kg) (P < 0.001). No highly significant changes on blood glucose
levels were noticed in normal rats after both acute and chronic
treatments with CS and CC. In addition, no changes were observed in
basal plasma insulin concentrations after treatment with these plants
in either normal or STZ diabetic rats indicating that the underlying
mechanism of this pharmacological activity seems to be independent of
insulin secretion. We conclude that aqueous extracts of CC and CS
exhibit a potent anti-hyperglycaemic activity in STZ rats without
affecting basal plasma insulin concentrations. |
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Diseases |
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Disease Link |
