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DiaMedBase ID |
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DMPCf143 |
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Medicinal Plant
|
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Artemisia roxburghiana, Salvia
coccinia, Monstera deliciosa, Abies pindrow, Centaurea iberica,
Euphorbia helioscopia, Bauhinia variegate, Bergenia himalacia,
Taraxacum officinale, Viburnum foetens, Adhatoda vasica, Cassia
fistula, Chrysanthemum leucanthemum, Morus alba, Plectranthus
rugosus, Peganum harmala and Olea ferruginea |
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Plant part(s)
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Whole plant |
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Objective |
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To know the effects of medicinal plants
on diabetes |
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Journal Source
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Phytother
Res,
2004; 18(1):73-77 |
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Title
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The effect of medicinal plants of
Islamabad and Murree region of Pakistan on insulin secretion from
INS-1 cells |
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Authors
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Hussain Z, Waheed A, Qureshi RA, Burdi
DK, Verspohl EJ, Khan N, Hasan M |
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Address
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Department of Chemistry, Quaid-i-Azam
University, Islamabad Pakistan. chem63@yahoo.com |
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Abstract
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In vitro testing of the extracts of
medicinal plants collected from Islamabad and the Murree region on
insulin secretagogue activity was carried out. Dried ethanol extracts
of all plants (ZH1-ZH19) were dissolved in ethanol and DMSO, and
tested at various concentrations (between 1 and 40 microg/mL) for
insulin release from INS-1 cells in the presence of 5.5 mM glucose.
Glibenclamide was used as a control. Promising insulin secretagogue
activity in various plant extracts at 1, 10, 20 and 40 microg/mL was
found, while in some cases a decrease in insulin secretion was also
observed. Artemisia roxburghiana, Salvia coccinia and Monstera
deliciosa showed insulin secretagogue activity at 1 microg/mL (p <
0.05) while Abies pindrow, Centaurea iberica and Euphorbia helioscopia
were active at 10 microg/mL (p < 0.05). Extracts of Bauhinia variegata
and Bergenia himalacia showed effects at 20 microg/mL (p < 0.05), and
Taraxacum officinale and Viburnum foetens at 40 microg/mL (p < 0.05).
Insulin secretagogue activity could not be detected in the extracts of
Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus
alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea. The
results suggest that medicinal plants of Islamabad and the Murree
region of Pakistan may be potential natural resources for antidiabetic
compounds. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCa144 |
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Medicinal Plant
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Momordica charantia, Melia azadirachta, Pterocarpus marsupium,
Tinospora cordifolia , Gymnema sylvestre, Enicostemma littorale,
Emblica officinalis, Eugenia jambolana, Cassia auriculata and
Curcuma longa |
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Plant part(s)
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Whole plant
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Objective |
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To
investigate the antihyperglycaemic and antioxidant activity in STZ-induced
diabetic rats |
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Journal Source
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J Pharm Pharmacol,
2004; 56(11):1435-1442 |
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Title
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Antihyperglycaemic and antioxidant
effect of hyponidd, an ayurvedic herbomineral formulation in
streptozotocin-induced diabetic rats |
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Authors
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Babu
PS, Stanely Mainzen Prince P |
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Address
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Department of Biochemistry, Annamalai
University, Annamalai Nagar-608 002, Tamil Nadu, India |
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Abstract
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Hyponidd is a herbomineral formulation
composed of the extracts of ten medicinal plants ( Momordica charantia,
Melia azadirachta, Pterocarpus marsupium, Tinospora cordifolia ,
Gymnema sylvestre, Enicostemma littorale, Emblica officinalis, Eugenia
jambolana, Cassia auriculata and Curcuma longa). We have investigated
hyponidd for its possible antihyperglycaemic and antioxidant effect in
diabetic rats. Rats were rendered diabetic by streptozotocin (STZ) (45
mg kg(-1) body weight). Oral administration of hyponidd (100 mg kg(-1)
and 200 mg kg(-1)) for 45 days resulted in significant lowered levels
of blood glucose and significant increased levels of hepatic glycogen
and total haemoglobin. An oral glucose tolerance test was also
performed in experimental diabetic rats in which there was a
significant improvement in blood glucose tolerance in the rats treated
with hyponidd. Hyponidd administration also decreased levels of
glycosylated haemoglobin, plasma thiobarbituric acid reactive
substances, hydroperoxides, ceruloplasmin and alpha-tocopherol in
diabetic rats. Plasma reduced glutathione and vitamin C were
significantly elevated by oral administration of hyponidd. The effect
of hyponidd at a dose of 200 mg kg(-1) was more effective than
glibenclamide (600 microg kg(-1)) in restoring the values to near
normal. The results showed that hyponidd exhibits antihyperglycaemic
and antioxidant activity in STZ-induced diabetic rats. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCt145 |
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Medicinal Plant
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Cassia tora |
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Plant part(s)
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Fiber |
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Objective |
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To
study the effect of serum lipids in korean diabetic patients. |
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Journal Source
|
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Journal of
Medicinal Food,
2005;
8(3): 311-318 |
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Title
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Effects of Cassia tora Fiber Supplement on Serum Lipids in
Korean Diabetic Patients |
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Authors
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Sung-Hee Cho1,
Tae-Hee Kim1, Nan-Hee Lee1,
Ho-Sang Son2, Il-Jin Cho3, Tae-Youl Ha3 |
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Address
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1Department
of Food Science and Nutrition, Catholic University of Daegu, Gyeongbuk,
2Department of Medicine, Catholic University of
Daegu, Daegu, 3Korea Food Research Institute,
Gyeonggi-do, Korea |
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Abstract
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Cassia tora fiber supplement
consisting of 2 g of soluble fiber extracted from Cassia semen (C.
tora L.), 200 mg of  -tocopherol,
500 mg of ascorbic acid, and 300 mg of maltodextrin was formulated in
a pack, and given to 15 type II diabetic subjects (seven men and eight
women 57.1 ± 2.9 years old) with instructions to take two packs per
day for 2 months. Placebo contained maltodextrin only with a little
brown caramel color. Lifestyle factors and dietary intakes of the
subjects were not altered during the 2-month period. Serum total
cholesterol was moderately (P < .1) decreased in the C. tora
group compared with the age- and gender-matched placebo group, as was
the ratio of apolipoprotein B to apolipoprotein A1 (P < .1).
Levels of serum triglycerides and low-density lipoprotein-cholesterol
tended to decrease more in the C. tora-supplemented group than
in the placebo group. Serum -tocopherol
was increased (P < .01) but lipid peroxides were not
significantly lower in the C. tora group. Fasting blood
glucose, hemoglobin A1c, blood urea nitrogen, creatinine, and
activities of serum aspartate aminotransferase and alanine
aminotransferase were not changed by the fiber supplement. We
concluded that C. tora supplements can help improve serum lipid
status in type II diabetic subjects without serious adverse effects. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCa146 |
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Medicinal Plant
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Gymnema sylvestre, Eugenia jambolana, Momordica charantia, Azadirachta
indica, Cassia auriculata, Aegle marmelose, Withania somnifera
and Curcuma longa |
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Plant part(s)
|
|
Leaves |
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Objective |
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To
study the hypoglycemic activity in normal and streptozotocin induced
diabetic mice |
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Journal Source
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Phytother,
2005; 19(5):409-415 |
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Title
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Effect of Dianex, a herbal formulation
on experimentally induced diabetes mellitus |
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Authors
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Mutalik S, Chetana M, Sulochana B, Devi PU, Udupa N |
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Address
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College of Pharmaceutical Sciences, Manipal, Karnataka, India |
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Abstract
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Dianex, a polyherbal formulation consisting of the aqueous extracts of
Gymnema sylvestre, Eugenia jambolana, Momordica charantia Azadirachta
indica, Cassia auriculata, Aegle marmelose, Withania somnifera and
Curcuma longa was screened for hypoglycemic activity in normal and
streptozotocin induced diabetic mice. Dianex was administered in
different doses of 100-500 mg/kg/day orally in acute (6 h) and
long-term (6 weeks) studies. Blood glucose levels were checked 2-6 h
after treatment in acute studies and every 2 weeks in long-term
studies. Body weight was recorded on the first and final day of the
treatment in the long-term studies with diabetic mice. After 6 weeks,
high-density lipoprotein, triglycerides, total cholesterol, alanine
transaminase (ALT), aspertate transaminase (AST), urea and creatinine
were estimated in serum of the diabetic mice. Glycogen and total
protein levels were estimated in the liver. Also, the liver and
pancreas was subjected to histological examination. Oral glucose
tolerance and in vitro free radical scavenging activity was also
studied.Dianex produced significant (p<0.05) hypoglycemic activity at
250-500 mg/kg doses in both normal and diabetic mice in acute and
long-term studies. The body weight of diabetic mice significantly
(p<0.05) increased with all tested doses of Dianex. The elevated
triglycerides, cholesterol, ALT, AST, urea and creatinine levels in
diabetic mice were significantly (p<0.05) reduced at the doses of 250
and 500 mg/kg. The liver glycogen and protein levels were both
significantly (p<0.05) increased in diabetic mice at 250 and 500 mg/kg
doses. Dianex increased the glucose tolerance significantly (p<0.05)
in both normal and diabetic mice at all the doses tested.
Histopathological examination showed that the formulation decreased
streptozotocin induced injury to the tissues at all the doses tested.
It produced significant (p<0.05) free radical scavenging activity
against ABTS+, DPPH and hydroxyl free radicals at the concentrations
ranging between 10-1000 microg/ml.Thus, in the present study, Dianex
produced significant hypoglycemic activity in both normal and diabetic
animals. It also reversed other diabetic complications in diabetic
mice at 250 and 500 mg/kg doses. In our earlier study, Dianex was well
tolerated in laboratory animals at higher doses (upto 10 g/kg in mice,
acute toxicity; up to 2.5 g/kg in rats, subacute toxicity studies for
30 days) without exhibiting any toxic manifestation. Hence, Dianex may
be useful in the treatment of diabetes mellitus. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCa147 |
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Medicinal Plant
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Cassia alata |
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Plant part(s)
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Leaves |
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Objective |
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To
study the hypoglycemic effect |
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Journal Source
|
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J Ethnopharmacol.,
1988; 22(1):81-90 |
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Title
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Effect of Cassia alata leaf extract on hyperglycemic rats |
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Authors
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Palanichamy S, Nagarajan S, Devasagayam M |
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Address
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Department of Chemistry, Bharathidasan University, Tiruchirapalli,
India |
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Abstract
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The oral effectiveness of
Cassia alata leaf extract on streptozotocin-induced hyperglycemia in
rats has been studied and the results compared with glybenclamide.
While the extract has no effect on glucose levels in normoglycemic
animals, it reduced the blood sugar value in streptozotocin-induced
hyperglycemic animals. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCo148 |
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Medicinal Plant
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Bearberry (Arctostaphylos uva-ursi), golden seal (Hydrastis canadensis),
mistletoe (Viscum album), tarragon (Artemisia dracunculus), bayberry
(Cinnamomum tamala), meadowsweet (Filipendula ulmaria), senna (Cassia
occidentalis) |
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Plant part(s)
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Herbal mixture of all plants |
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Objective |
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To
study blood glucose levels |
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Journal Source
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Acta
Diabetol Lat.,
1989; 26(1):51-55 |
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Title
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Evaluation of traditional plant
treatments for diabetes: studies in streptozotocin diabetic mice |
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Authors
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Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR |
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Address
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Department of Biological and Biomedical
Sciences, University of Ulster, Coleraine, U.K |
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Abstract
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Seven plants and a herbal
mixture used for traditional treatment of diabetes were studied in
streptozotocin diabetic mice. The treatments were supplied as 6.25% by
weight of the diet for 9 days. Consumption of diets containing
bearberry (Arctostaphylos uva-ursi), golden seal (Hydrastis canadensis),
mistletoe (Viscum album) and tarragon (Artemisia dracunculus)
significantly reduced the hyperphagia and polydipsia associated with
streptozotocin diabetes, but bayberry (Cinnamomum tamala), meadowsweet
(Filipendula ulmaria), senna (Cassia occidentalis) and the herbal
mixture did not alter these parameters. Bearberry, mistletoe and
tarragon retarded the body weight loss but none of the eight
treatments significantly altered plasma glucose or insulin
concentrations. These studies suggest that bearberry, golden seal,
mistletoe and tarragon may counter some of the symptoms of
streptozotocin diabetes without, however, affecting glycemic control. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCf149 |
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Medicinal Plant
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Cajanus cajan L. and
Cassia fistula L |
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Plant part(s)
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Leaves
and Stems |
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Objective |
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To
study the effects of Cajanus cajan L. and of Cassia fistula L. on
carbohydrate metabolism in mice |
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Journal Source
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Rev Med Panama.
1991; 16(1):39-45 |
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Title
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Evaluation of traditional medicine:
effects of Cajanus cajan L. and of Cassia fistula L. on carbohydrate
metabolism in mice |
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Authors
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Esposito Avella M, Diaz A, de Gracia I, de Tello R, Gupta MP |
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Address
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Departamento de Farmacologia, Universidad de Panama |
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Abstract
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The authors report the results of
pharmacologic evaluation of two medicinal plants: Cajanus cajan (L.)
Millsp and Cassia fistula, which are used in Panamanian folk medicine
for the treatment of diabetes. It was found that the aqueous fraction
of the leaves and stems of C. cajan did not produce any hypo blood
sugar effect in normoglycemic mice; instead, it produced a
hyperglycemia with doses of 500 mg/kg and 1000 mg/kg (p less than
0.001). Only with a dose of 300 mg/kg a short lived decrease in the
glycemia was seen at one hour. On the contrary, the folk use of the
leaves of C. fistula for diabetes seems to have some correlation with
the popular frek use. The aqueous fraction produced a significant
decrease in the glycemia (p less than 0.001) at 4 and 24 hours with
doses of 300 and 500 mg/kg, and at one and four hours after the dose
of 1000 mg/kg (p less than 0.001). In the glucose tolerance test, the
aqueous fraction of C. cajan produced a significant and short lasting
decrease (p less than 0.05) with the dose of 300 mg/kg, while the dose
of 500 mg/kg did at 0.25, 0.5 and 1 hour (p less than 0.01). The 1000
mg/kg dose produced a significant increase in glucose tolerance at 1
and 2 hours (p less than 0.05). The aqueous fraction of C. fistula
produced a significant decrease (p less than 0.05) with the dose of
500 mg/kg at 0.25 and 0.5 hours. The 1000 mg/kg dose produced a
significant increase (p less than 0.001) at 0.25 and 2 hours. |
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Diseases |
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Disease Link |
|
DiaMedBase ID |
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DMPCa150 |
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Medicinal Plant
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Azardirachta indica, Cassia auriculata and Momordica
charantia |
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Plant part(s)
|
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Leaves |
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Objective |
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To investigate Diamed for its possible
antihyperglycaemic action in rats with alloxan-induced experimental
diabetes |
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Journal Source
|
|
J Pharm Pharmacol,
2001; 53(8):1139-1143 |
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Title
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Antihyperglycaemic effect of Diamed, a herbal formulation, in
experimental diabetes in rats |
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Authors
|
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Pari
L, Ramakrishnan R, Venkateswaran S |
|
Address
|
|
Department of Biochemistry, Annamalai
University, Tamil Nadu, India. paribala@sancharnet.in |
|
Abstract
|
|
Diamed is a herbal formulation composed
of the aqueous extracts of three medicinal plants (Azardirachta indica,
Cassia auriculata and Momordica charantia). We have investigated
Diamed for its possible antihyperglycaemic action in rats with alloxan-induced
experimental diabetes. Oral administration of Diamed (1.39 (0.25 g),
1.67 (0.30 g) or 1.94 (0.35 g) mL kg(-1)) for 30 days resulted in a
significant reduction in blood glucose, glycosylated haemoglobin, and
an increase in plasma insulin and total haemoglobin. The effect was
highly significant after administration of the 1.94 mL (0.35 g) g(-1)
body weight dose. Diamed also prevented a decrease in body weight. An
oral glucose tolerance test was performed in experimental diabetic
rats in which there was a significant improvement in glucose tolerance
in the animals treated with Diamed. The effect was compared with 600
microg kg(-1) glibenclamide. The results showed that Diamed had
antihyperglycaemic action in experimental diabetes in rats. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCa151 |
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Medicinal Plant
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Cassia auriculata |
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Plant part(s)
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Flower |
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Objective |
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To
study the effect of Cassia auriculata
flower extract (CFEt) on hepatic glycolytic and gluconeogenic enzymes |
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Journal Source
|
|
Clinical and Experimental Pharmacology
and Physiology,
2003; 30(1-2):38 |
|
Title
|
|
Antihyperglycaemic
effect of Cassia auriculata in experimental diabetes and its
effects on key metabolic enzymes involved in carbohydrate metabolism |
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Authors
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Muniappan Latha and
Leelavinothan Pari |
|
Address
|
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Department of Biochemistry, Faculty of Science,
Annamalai University, Annamalai Nagar, Tamil Nadu, India |
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Abstract
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1. In experimental
diabetes, enzymes of glucose and fatty acid metabolism are markedly
altered. Persistent hyperglycaemia is a major contributor to such
metabolic alterations, which lead to the pathogenesis of diabetic
complications. To our knowledge, there are no available reports on the
enzymes of hepatic glucose metabolism of Cassia auriculata
flower against diabetes. The present study was designed to study the
effect of Cassia auriculata flower extract (CFEt) on hepatic
glycolytic and gluconeogenic enzymes. 2. Streptozotocin diabetic rats
were given CFEt (0.15, 0.30 and 0.45 g/kg) or 600 µg/kg glibenclamide
for 30 days. At the end of 30 days, blood glucose, plasma insulin,
haemoglobin, glycosylated haemoglobin, glycolytic and gluconeogenic
enzymes were assessed. 3. Administration of CFEt at 0.45 g/kg
significantly decreased blood glucose, glycosylated haemoglobin and
gluconeogenic enzymes and increased plasma insulin, haemoglobin and
hexokinase activity. Similarly, administration of glibenclamide showed
a significant effect; however, CFEt at 0.15 and 0.30 g/kg did not show
any significant effect. 4. In conclusion, the observations show that
the aqueous extract of CFEt possesses an antihyperglycaemic effect and
suggest that enhanced gluconeogenesis during diabetes is shifted
towards normal and that the extract enhances the utilization of
glucose through increased glycolysis. The effect of CFEt was more
prominent than that of glibenclamide. |
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Diseases |
|
Disease Link |
|
