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DiaMedBase ID |
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DMPCa741 |
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Medicinal Plant
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Xanthocercis zambesiaca, Morus bombycis,
Aglaonema treubii,
and
Castanospermum australe
. |
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Plant part(s)
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Leaves and roots |
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Objective |
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To study the
Antihyperglycemic effects of N-containing sugars from Xanthocercis
zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum
australe in streptozotocin-diabetic mice |
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Journal Source
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J Nat Prod.
1998 Mar;61(3):397-400 |
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Title
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Antihyperglycemic effects of N-containing sugars from Xanthocercis
zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum
australe in streptozotocin-diabetic mice |
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Authors
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Nojima H, Kimura I,
Chen FJ, Sugihara Y, Haruno M, Kato A, Asano N |
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Address
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Department of
Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama
Medical and Pharmaceutical University, Japan |
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Abstract
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The aqueous MeOH
extract of the leaves and root of Xanthocercis zambesiaca (Leguminosae)
and eight structurally related nitrogen-containing sugars, fagomine
(1), 4-O-beta-D-glucopyranosylfagomine (2),
3-O-beta-D-glucopyranosylfagomine (3), 3-epifagomine (4),
2,5-dideoxy-2,5-imino-D-mannitol (5), castanospermine (6), alpha-homonojirimycin
(7), and 1-deoxynojirimycin (8) were evaluated for antihyperglycemic
effects in streptozotocin (STZ)-diabetic mice. The insulin-releasing
effects of 1 were also investigated. The blood glucose level fell
after i.p. injection of the extract (50 mg/kg). Compounds 1, 2, 5, and
6 reduced the blood glucose level after i.p. injection of 150 mumol/kg.
Compound 1 increased plasma insulin level in STZ-diabetic mice and
potentiated the 8.3-mM glucose-induced insulin release from the rat
isolated-perfused pancreas. The 1-induced potentiation of insulin
release may partly contribute to antihyperglycemic action. |
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Diseases |
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Disease Link |
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