|
|
|
|
DiaMedBase ID |
|
DMPCr152 |
|
Medicinal Plant
|
|
Catharanthus roseus Linn |
|
Plant part(s)
|
|
Leaves |
|
Objective |
|
To
evaluate the hypoglycemic
activity of
Catharanthus roseus Linn.
leaves in normal
and alloxan-induced diabetic rabbits |
|
Journal Source
|
|
BMC Complementary and
Alternative Medicine
2003; 3:4 |
|
Title
|
|
The
juice of fresh leaves of Catharanthus roseus Linn. reduces
blood glucose in normal and alloxan diabetic rabbits |
|
Authors
|
|
Srinivas
Nammi1, Murthy K Boini1, Srinivas D Lodagala1
and Ravindra Babu S Behara2 |
|
Address
|
|
1Pharmacology
Division, Department of Pharmaceutical Sciences Andhra University,
Visakhapatnam-530 003, Andhra Pradesh, INDIA
2Current address: A15, Faculty of Pharmacy, University of
Sydney, Sydney, NSW-2006 AUSTRALIA |
|
Abstract
|
|
Background
The leaf juice or water decoction of
Catharanthus roseus L. (Apocyanaceae) is used as a folk
medicine for the treatment of diabetes all over the world. In the
present investigation, the leaf juice of C. roseus has been
evaluated for its hypoglycemic activity in normal and alloxan-induced
diabetic rabbits.
Methods
The blood glucose lowering activity of
the leaf juice was studied in normal and alloxan-induced (100 mg/kg,
i.v.) diabetic rabbits, after oral administration at doses of 0.5,
0.75 and 1.0 ml/kg body weight. Blood samples were collected from the
marginal ear vein before and also at 4, 6, 8, 10, 12, 16, 18, 20 & 24
h after drug administration and blood glucose was analyzed by Nelson-Somogyi's
method using a visible spectrophotometer. The data was compared
statistically by using Student's t-test.
Results The leaf juice of C.
roseus produced dose-dependent reduction in blood glucose of both
normal and diabetic rabbits and comparable with that of the standard
drug, glibenclamide. The results indicate a prolonged action in
reduction of blood glucose by C. roseus and the mode of action
of the active compound(s) of C. roseus is probably mediated
through enhance secretion of insulin from the β-cells
of Langerhans or through extrapancreatic mechanism.
Conclusions
The present study clearly indicated a
significant antidiabetic activity with the leaf juice of
Catharanthus roseus and supports the traditional usage of the
fresh leaves by Ayurvedic physicians for the control of diabetes. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCr153 |
|
Medicinal Plant
|
|
Catharanthus roseus,
Trigonella foenum graecum |
|
Plant part(s)
|
|
Leaves, Seeds |
|
Objective |
|
To study the hypoglycemic
action of leaf juice of Catharanthus roseus and the seed powder of
fenugreek on diabetes |
|
Journal Source
|
|
Pharmaceutical
Biology (Formerly International Journal of Pharmacognosy),
2003; 41(6):466-472 |
|
Title
|
|
Evaluation of Herbal
Preparations for Hypoglycemic Activity in Normal and Diabetic Rabbits |
|
Authors
|
|
S. Satyanarayana, G.S.
Sarma, A. Ramesh, K. Sushruta, N. Srinivas |
|
Address
|
|
Not available |
|
Abstract
|
|
The leaf juice of
Catharanthus roseus and the seed powder of fenugreek were tested for
their hypoglycemic action individually and in combination in normal
and alloxan-induced diabetic rabbits. Blood glucose was determined in
all the groups before and after treatment with Catharanthus roseus and
fenugreek at doses of 0.5, 0.75 and 1.0ml/kg and 50, 100 and 150
mg/kg, respectively, at 0, 0.5, 1, 2, 3, 4, 6, 8, 10, 12, 14, 16, 18,
20, 22 and 24 h after being fasted for 18 h. The effect was found to
be dose-dependent with both the treatments at the doses administered.
The percentage blood glucose reduction produced by the combination of
Catharanthus roseus (0.5 ml/kg) and fenugreek (50mg/kg) was more than
the sum of their individual percent blood glucose reduction in both
normal and diabetic rabbits, suggesting that the combination produced
a synergistic action. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCr154 |
|
Medicinal Plant
|
|
Catharanthus roseus |
|
Plant part(s)
|
|
Leaves, Twigs and Flowers |
|
Objective |
|
To study the hypoglycaemic
activity of leaves and twigs of Catharanthus roseus |
|
Journal Source
|
|
Journal of Ethnopharmacology
2001; 76:269-277 |
|
Title
|
|
Effect of an antidiabetic extract of
Catharanthus roseus on enzymic activities in streptozotocin
induced diabetic rats |
|
Authors
|
|
Som Nath Singh, Praveen Vats, Shoba Suri, Radhey Shyam,
M.M.L. Kumria, S. Ranganathan, K. Sridharan |
|
Address
|
|
Defence Institute of Physiology and Allied Sciences,
Lucknow Road, Timarpur, Delhi 110054, India |
|
Abstract
|
|
Hypoglycemic activity was detected in
dichloromethane:methanol extract (1:1) of leaves and twigs of
Catharanthus roseus (family Apocynaceae), a traditionally used
medicinal plant, using streptozotocin (STZ) induced diabetic rat
model. Extract at dose 500 mg/kg given orally for 7 and 15 days showed
48.6 and 57.6% hypoglycemic activity, respectively. Prior treatment at
the same dose for 30 days provided complete protection against STZ
challenge (75 mg/kg/i.p.×1). Enzymic activities of glycogen synthase,
glucose 6-phosphate-dehydrogenase, succinate dehydrogenase and malate
dehydrogenase were decreased in liver of diabetic animals in
comparison to normal and were significantly improved after treatment
with extract at dose 500 mg/kg p.o. for 7 days. Results indicate
increased metabolization of glucose in treated rats. Increased levels
of lipid peroxidation measured as 2-thiobarbituric acid reactive
substances (TBARS) indicative of oxidative stress in diabetic rats
were also normalized by treatment with the extract. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCr155 |
|
Medicinal Plant
|
|
Burdock (Arctium lappa), cashew (Anacardium occidentale), dandelion (Taraxacum
officinale), elder (Sambucus nigra), fenugreek (Trigonella
foenum-graecum), guayusa (Ilex guayusa), hop (Humulus lupulus), nettle
(Urtica dioica), cultivated mushroom (Agaricus bisporus), periwinkle (Catharanthus
roseus), sage (Salvia officinale), and wild carrot (Daucus
carrota) |
|
Plant part(s)
|
|
Whole
plant |
|
Objective |
|
To
study the glycemic effect |
|
Journal Source
|
|
Diabetes Res.,
1989; 10(2):69-73 |
|
Title
|
|
Glycaemic effects of traditional European plant treatments for
diabetes. Studies in normal and streptozotocin diabetic mice |
|
Authors
|
|
Swanston-Flatt SK, Day C, Flatt PR, Gould BJ, Bailey CJ |
|
Address
|
|
Department of Biochemistry, University of Surrey, Guildford, UK |
|
Abstract
|
|
Twelve plants used for the
traditional treatment of diabetes mellitus in northern Europe were
studied using normal and streptozotocin diabetic mice to evaluate
effects on glucose homeostasis. The plants were administered in the
diet (6.25% by weight) and/or as decoctions or infusions in place of
drinking water, to coincide with the traditional method of
preparation. Treatment for 28 days with preparations of burdock (Arctium
lappa), cashew (Anacardium occidentale), dandelion (Taraxacum
officinale), elder (Sambucus nigra), fenugreek (Trigonella
foenum-graecum), guayusa (Ilex guayusa), hop (Humulus lupulus), nettle
(Urtica dioica), cultivated mushroom (Agaricus bisporus), periwinkle
(Catharanthus roseus), sage (Salvia officinale), and wild carrot
(Daucus carrota) did not affect the parameters of glucose homeostasis
examined in normal mice (basal plasma glucose and insulin, glucose
tolerance, insulin-induced hypoglycaemia and glycated haemoglobin).
After administration of streptozotocin (200 mg/kg) burdock and nettle
aggravated the diabetic condition, while cashew, dandelion, elder,
fenugreek, hop, periwinkle, sage and wild carrot did not significantly
affect the parameters of glucose homeostasis studied (basal glucose
and insulin, insulin-induced hypoglycaemia, glycated haemoglobin and
pancreatic insulin concentration). Guayusa and mushroom retarded the
development of hyperglycaemia in streptozotocin diabetes and reduced
the hyperphagia, polydipsia, body weight loss, and glycated
haemoglobin. Mushroom also countered the initial reduction in plasma
insulin and the reduction in pancreatic insulin concentration, and
improved the hypoglycaemic effect of exogenous insulin. These studies
suggest the presence of potentially useful antidiabetic agents in
guayusa and mushroom. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCr156 |
|
Medicinal Plant
|
|
Azadirachta indica,
Gymnema sylvestre, Catharanthus roseus
and
Ocimum sanctum |
|
Plant part(s)
|
|
Leaves |
|
Objective |
|
To study the comparison of blood sugar lowering activity of four
medicinal plants Azadirachta indica, Gymnema sylvestre, Catharanthus
roseus and Ocimum sanctum |
|
Journal Source
|
|
J Ethnopharmacol.
1999; 67(3):367-372 |
|
Title
|
|
A comparative
evaluation of some blood sugar lowering agents of plant origin |
|
Authors
|
|
Chattopadhyay RR |
|
Address
|
|
Biometry Research Unit, Indian
Statistical Institute, Calcutta |
|
Abstract
|
|
A comparison of blood sugar lowering activity of four important
medicinal plants (Azadirachta indica, Gymnema sylvestre, Catharanthus
roseus and Ocimum sanctum) were carried out against normal and
streptozotocin-induced diabetic rat models. The plant extracts
decreased the blood sugar level in varying degrees. Blood sugar
lowering unit (BLU) of activity of each leaf extract and tolbutamide
was calculated by ED50 values. Statistical analysis revealed
significant (P < 0.05) variation among the treatments as well as doses
with regard to their blood sugar lowering capacity. A. indica leaf
extract was found to have the most potent blood sugar-lowering
activity followed by C. roseus, G. sylvestre and O. sanctum. |
|
Diseases |
|
Disease Link |
|
