|
|
|
|
DiaMedBase ID |
|
DMPCc161 |
|
Medicinal Plant
|
|
Centaurea
corcubionensis |
|
Plant part(s)
|
|
Not available |
|
Objective |
|
To investigate the
hypoglycemic activity in rats |
|
Journal Source
|
|
Planta Med.
1988; 54(2):107-109 |
|
Title
|
|
Centaurea
corcubionensis: a study of its hypoglycemic activity in rats |
|
Authors
|
|
Chucla MT, Lamela M, Gato
A, Cadavid I |
|
Address
|
|
Not available |
|
Abstract
|
|
Not available |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCi162 |
|
Medicinal Plant
|
|
Artemisia roxburghiana, Salvia coccinia, Monstera deliciosa, Abies
pindrow, Centaurea iberica, Euphorbia helioscopia, Bauhinia
variegate, Bergenia himalacia, Taraxacum officinale, Viburnum foetens,
Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus
alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea |
|
Plant part(s)
|
|
Whole plant |
|
Objective |
|
To know the effects of medicinal plants
on diabetes |
|
Journal Source
|
|
Phytother
Res,
2004; 18(1):73-77 |
|
Title
|
|
The effect of medicinal plants of
Islamabad and Murree region of Pakistan on insulin secretion from
INS-1 cells |
|
Authors
|
|
Hussain Z, Waheed A, Qureshi RA, Burdi DK, Verspohl EJ, Khan N, Hasan
M |
|
Address
|
|
Department of Chemistry, Quaid-i-Azam
University, Islamabad Pakistan. chem63@yahoo.com |
|
Abstract
|
|
In vitro testing of the extracts of
medicinal plants collected from Islamabad and the Murree region on
insulin secretagogue activity was carried out. Dried ethanol extracts
of all plants (ZH1-ZH19) were dissolved in ethanol and DMSO, and
tested at various concentrations (between 1 and 40 microg/mL) for
insulin release from INS-1 cells in the presence of 5.5 mM glucose.
Glibenclamide was used as a control. Promising insulin secretagogue
activity in various plant extracts at 1, 10, 20 and 40 microg/mL was
found, while in some cases a decrease in insulin secretion was also
observed. Artemisia roxburghiana, Salvia coccinia and Monstera
deliciosa showed insulin secretagogue activity at 1 microg/mL (p <
0.05) while Abies pindrow, Centaurea iberica and Euphorbia helioscopia
were active at 10 microg/mL (p < 0.05). Extracts of Bauhinia variegata
and Bergenia himalacia showed effects at 20 microg/mL (p < 0.05), and
Taraxacum officinale and Viburnum foetens at 40 microg/mL (p < 0.05).
Insulin secretagogue activity could not be detected in the extracts of
Adhatoda vasica, Cassia fistula, Chrysanthemum leucanthemum, Morus
alba, Plectranthus rugosus, Peganum harmala and Olea ferruginea. The
results suggest that medicinal plants of Islamabad and the Murree
region of Pakistan may be potential natural resources for antidiabetic
compounds. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCa163 |
|
Medicinal Plant
|
|
Centaurea aspera |
|
Plant part(s)
|
|
Flowers |
|
Objective |
|
To
study the hypoglycaemic activity in normal and alloxan-diabetic rats |
|
Journal Source
|
|
Rev Esp Fisiol,
1976; 32(4):313-316 |
|
Title
|
|
Hypoglycaemic activity of centaurea aspera L (author's transl) |
|
Authors
|
|
Masso
JL, Adzet T |
|
Address
|
|
Not available |
|
Abstract
|
|
Two aqueous crude extracts of Centaurea
aspera L. flowers were tested for hypoglycaemic activity in normal and
alloxan-diabetic rats. Both extracts exert a significant hypoglycaemic
effect by oral route and chronic administration in diabetic rats, but
only the extract obtained by exhaustion with hot water displayed an
acute hypoglycaemic activity in normal animals. All plant-treated
groups were compared against glibenclamide as a standard. The acute
toxicity by oral and intravenous routes was determined in mice. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCc164 |
|
Medicinal Plant
|
|
Centaurea
corcubionensis |
|
Plant part(s)
|
|
Whole plant |
|
Objective |
|
To
study the hypoglycemic activity |
|
Journal Source
|
|
Planta
Med.,
1988; 54(2):107-109 |
|
Title
|
|
Centaurea corcubionensis: a study of its hypoglycemic activity in rats |
|
Authors
|
|
Chucla MT, Lamela M, Gato A, Cadavid I |
|
Address
|
|
Not available |
|
Abstract
|
|
Not available |
|
Diseases |
|
Disease Link |
|
