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DiaMedBase ID |
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DMPCn167 |
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Medicinal Plant
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Chamaemelum nobile |
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Plant part(s)
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Aerial parts |
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Objective |
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To investigate the effect
of aerial part of Chamaemelum nobile on blood glucose concentrations
and basal insulin levels in normal and streptozotocin-induced diabetic
rats |
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Journal Source
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Diabetes Res Clin Pract.
2005; 67(3):189-195 |
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Title
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Potent hypoglycaemic
activity of the aqueous extract of Chamaemelum nobile in normal and
streptozotocin-induced diabetic rats |
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Authors
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Eddouks M, Lemhadri A,
Zeggwagh NA, Michel JB |
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Address
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UFR: PNPE, BP 21,
Errachidia, Morocco 52000. m.eddouks@caramail.com |
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Abstract
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The purpose of this study
was to investigate the effect of both a single dose and daily oral
administration for 15 days of the aqueous extract of the aerial part
of Chamaemelum nobile (C. nobile) at a dose of 20mg/kg body weight on
blood glucose concentrations and basal insulin levels in normal and
streptozotocin-induced diabetic rats (STZ). Single oral administration
of C. nobile aqueous extract reduced blood glucose levels from 6.0 +/-
0.3 mmol/l to 4.9 +/- 0.09 mmol/l (P < 0.05) 6h after administration
in normal rats and from 21.1 +/- 1.3 mmol/l to 14.5 +/- 0.9 mmol/l (P
< 0.001) in STZ diabetic rats. Furthermore, blood glucose levels were
decreased from 6.1 +/- 0.06 mmol/l to 4.6 +/- 0.17 mmol/l (P < 0.01)
and from 21.1 +/- 1.31 mmol/l to 13.7 +/- 0.9 mmol/l (P < 0.01) in
normal and STZ diabetic rats, respectively, after 15 days of
treatment. Basal plasma insulin concentrations remain unchanged after
treatment in both normal and STZ diabetic rats so the mechanism of
this pharmacological activity seems to be independent of insulin
secretion. We conclude that the aqueous extract of C. nobile exhibits
a significant hypoglycaemic effect in normal and STZ diabetic rats
without affecting basal plasma insulin concentrations and support,
therefore, its traditional use by the Moroccan population. |
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Diseases |
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Disease Link |
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