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DiaMedBase ID |
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DMPCi170 |
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Medicinal Plant
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Chrysobalanus icaco |
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Plant part(s)
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Plant
extract |
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Objective |
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To
investigate the antiangiogenic potential of Chrysobalanus icaco
methanol extract in the chicken embrionary tissue |
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Journal Source
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Int
J Mol Med.
2000; 5(6):667-669 |
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Title
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Chrysobalanus icaco L. extract for antiangiogenic potential
observation |
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Authors
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Alves De Paulo S, Teruszkin Balassiano
I, Henriques Silva N, Oliveira Castilho R, Coelho Kaplan MA, Currie
Cabral M, da Costa Carvalho MG |
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Address
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Instituto de Biofisica Carlos Chagas Filho, Laboratorio de Controle da
Expressao Genica, Universidade Federal do Rio de Janeiro, Centro de
Ciencias da Saude, Bloco C, Cidade Universitaria, CEP 21949-900, Rio
de Janeiro, Brasil |
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Abstract
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Angiogenesis is an important process in
several physiological situations and it is also implicated in the
development of some diseases such as diabetes and cancer. This study
investigated the antiangiogenic potential of Chrysobalanus icaco
methanol extract in the chicken embrionary tissue. Clinical trials for
cancer treatment using drugs based on this mechanism are already in
progress. Chorioallantoic membrane model (CAM) of chicken embryos,
with C. icaco methanol extract in plastic diskes was used. The results
showed an average of 44% angiogenesis inhibition in CAM areas with the
plant extract compared to the controls. The data indicate that C.
icaco methanol extract reduce the formation of new blood vessels in
chicken chorioallantoic membrane. |
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Diseases |
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Disease Link |
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