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DiaMedBase ID |
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DMPCa171 |
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Medicinal Plant
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Cicer aretinum |
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Plant part(s)
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Whole
plant |
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Objective |
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To
evaluate the influence of a diet containing heated chickpea in a
dietary induced rat model of hypercholesterolemia |
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Journal Source
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Int
J Vitam Nutr Res,
1999;
69(6):403-411 |
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Title
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Lipid and glucose utilization in hypercholesterolemic rats fed a diet
containing heated chickpea (Cicer aretinum L.): a potential functional
food |
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Authors
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Zulet
MA, Macarulla MT, Portillo MP, Noel-Suberville C, Higueret P, Martinez
JA |
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Address
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Department of Physiology and Nutrition, University of Navarra,
Pamplona, Spain |
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Abstract
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This feeding trial evaluated the
influence of a diet containing heated chickpea in a dietary induced
rat model of hypercholesterolemia in order to assess some possible
protective and therapeutic effects on lipid and carbohydrate
metabolism disorders as found with other legumes. Rats fed a diet
enriched with coconut oil (25%) and cholesterol (1%) for 42 days (HH)
showed a situation of type IIa hyperlipoproteinemia. However, these
lipid alterations were improved in the hypercholesterolemic rats
receiving control (HC) and legume (HL) diets for 16 days. Moreover,
results confirm that the chickpea was more effective than the control
diet containing casein in the normalization of triglycerides as well
as total and LDL-cholesterol levels. On the other hand, the HH group
showed a marked reduction in the liver glycogen content and
Glucose-6-Phase activity (involved in glyconeogenesis) and an increase
in Glucokinase (GK) activity (involved in glucose utilization). In
contrast, the rats receiving chickpea re-established the liver
glycogen deposition as compared to the HH group. Also, the chickpea
intake increased the GK activity as compared to the control diet. The
overall results support that chickpea intake may be recommended in
humans with altered lipid profile such as type IIa
hyperlipoproteinemia. Additionally, data concerning carbohydrate
utilization indicated its potential positive effects in diabetes
therapy and their role as biological active food supplements. |
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Diseases |
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Disease Link |

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