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DiaMedBase ID |
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DMPCs176 |
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Medicinal Plant
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Cissus sicyoides |
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Plant part(s)
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Leaves |
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Objective |
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To investigate the effects
of leaf decoctions treatment on the physiological and metabolic
parameters that are altered in diabetic animals |
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Journal Source
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Biotechnol Appl
Biochem.
2003; 37(Pt 1):15-20 |
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Title
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Cissus sicyoides
(princess vine) in the long-term treatment of streptozotocin-diabetic
rats |
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Authors
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Pepato MT, Baviera AM,
Vendramini RC, Perez Mda P, Kettelhut Ido C, Brunetti IL |
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Address
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Departamento de Analises
Cli;nicas, Faculdade de Ciencias Farmaceuticas de Araraquara,
Universidade Estadual Paulista Julio de Mesquita Filho, UNESP, Rua
Expedicionarios do Brasil n. 1621, Araraquara-CEP 14801-902-SP,
Brazil. pepatomt@fcfar.unesp.br |
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Abstract
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Leaf decoctions of Cissus
sicyoides (princess vine) are taken widely as a popular remedy for
diabetes mellitus in Brazil, where its common name is 'vegetal
insulin'. However, there have been practically no attempts so far to
determine scientifically whether it has anti-diabetic effects and we
decided to administer leaf decoctions, over extended periods, to
normal and streptozotocin-diabetic rats, and investigate the effects
of this treatment on the physiological and metabolic parameters that
are altered in diabetic animals. The experimental model adopted was
shown to be appropriate by running a parallel treatment with insulin,
which led to expected improvements in several abnormal parameter
values. The decoction treatment significantly reduced the intake of
both food and fluid and the volume of urine excreted, as well as the
levels of blood glucose, urinary glucose and urinary urea, in
comparison with controls. Lipid metabolism was not affected by the
treatment; nor was the level of hepatic glycogen in diabetic animals,
which indicated that the mechanism responsible for the improvement in
carbohydrate metabolism, observed in animals treated with the
decoction, could not involve inhibition of glycogenolysis and/or
stimulation of glycogenesis. The fact that normal animals treated with
C. sicyoides exhibited no changes in any of the measured parameters
suggests that its mode of action in diabetic animals does not resemble
those of sulphonylurea or insulin. It may, however, act in a similar
way to biguanide, via inhibition of gluconeogenesis. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCs733 |
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Medicinal Plant
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Cissus sicyoides |
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Plant part(s)
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Leaves |
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Objective |
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To
study the hypoglycemic effects of leaf extract |
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Journal Source
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BMC
Pharmacol,
2004; 4:9 |
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Title
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Hypoglycemic and anti-lipemic effects of
the aqueous extract from Cissus sicyoides |
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Authors
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Viana
GS, Medeiros AC, Lacerda AM, Leal LK, Vale TG, Matos FJ |
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Address
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Department of
Biophysiology, Faculty of Medicine of Juazeiro do Norte - FMJ, Av,
Leao Sampaio s/n, Juazeiro do Norte 63,040, Ceara, Brazil.
osorio@roadnet.com.br |
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Abstract
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Cissus sicyoides (Vitaceae) is a
medicinal plant popularly known in Brazil as "cipo-puca, anil-trepador,
cortina, and insulina". The plant is used in several diseases,
including rheumatism, epilepsy, stroke and also in the treatment of
diabetes. In the present work, we studied the hypoglycemic and anti-lipemic
effects of the aqueous extract prepared from fresh leaves of the plant
(AECS), in the model of alloxan-induced diabetes in rats. In addition,
hepatic enzyme levels were also determined. Results showed that the
daily treatment of diabetic rats with AECS for 7 days (100 and 200
mg/kg, p.o.) significantly decreased blood glucose levels in 25 and
22% respectively, as compared to the same groups before AECS
treatment. No significant changes were seen in control diabetic rats
before (48 h after alloxan administration) and after distilled water
treatment. While no changes were seen in total cholesterol levels, a
significant decrease was observed in plasma triglyceride levels, in
the alloxan-induced diabetic rats after AECS treatment with both
doses, as compared to the same groups before treatment. Significant
decreases in blood glucose (25%) and triglyceride levels (48%) were
also observed in the alloxan-induced diabetic rats after 4 days
treatment with AECS (200 mg/kg, p.o.). Aspartate (AST) and alanine
(ALT) aminotransferases levels, in diabetic controls and AECS-treated
rats, were in the range of reference values presented by normal rats.
The results justify the popular use of C. sicyoides, pointing out to
the potential benefit of the plant aqueous extract (AECS) in
alternative medicine, in the treatment of type 2 diabetes mellitus. |
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Diseases |
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Disease Link |
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