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DiaMedBase ID |
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DMPCc177 |
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Medicinal Plant
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Citrullus colocynthis |
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Plant part(s)
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Fruits |
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Objective |
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To
study the hypoglycaemic effect of aqueous extract of the rind of C.
colocynthis |
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Journal Source
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J Ethnopharmacol,
2000; 71(1-2):325-330 |
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Title
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The hypoglycaemic and antihyperglycaemic effect of citrullus
colocynthis fruit aqueous extract in normal and alloxan diabetic
rabbits |
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Authors
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Abdel-Hassan IA, Abdel-Barry JA, Tariq Mohammeda S |
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Address
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Chemistry Department, College of Science, University of Basrah, Basrah,
Iraq |
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Abstract
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Effects of the aqueous, glycosidic,
alkaloidal and saponin extracts of the rind of Citrullus colocynthis
on the plasma glucose levels were investigated in normal rabbits,
while the effects of saponin extract on the fasting plasma glucose
levels were studied in alloxan induced diabetic rabbits. In normal
rabbits, oral administration of aqueous extract (300 mg/kg) produced
significant reduction in plasma glucose after 1 h and highly
significant after 2,3 and 6 h. Phytochemical screening revealed that
the rind of C. colocynthis and its aqueous extract contains tertiary
and quaternary alkaloids, glycoside and saponin components. The
hypoglycaemic effects of these components given orally at a dose (50
mg/kg) were studied in normoglycaemic rabbits. Result showed that the
alkaloidal extract did not significantly lower the blood glucose
levels from 132 mg/100 ml at 0 h to 120 mg/100 ml after 6 h, while the
glycosidic extract significantly lowered the fasting glucose levels
after 2 and 3 h and highly significant after 6 h. The effect was more
pronounced with saponin extract, the saponin significantly lowered the
fasting glucose levels after 1 and 2 h and highly significant
(P<0.001) after 3 and 6 h. Graded doses (10, 15 and 20 mg/kg) of
saponin extract, when given orally to alloxan diabetic rabbits,
produced a significant reduction of plasma glucose concentration.
These results suggest that the aqueous extract of the rind of C.
colocynthis possesses a hypoglycaemic effect and its hypoglycaemic
action could be attributed for more extent to the presence of saponin
in addition to the presence of glycosidic components. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCc178 |
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Medicinal Plant
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Citrullus colocynthis |
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Plant part(s)
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Seeds |
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Objective |
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To examine the effect of
the aqueous extract of the seed of C. colocynthis on diabetes |
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Journal Source
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Molecular and
Cellular Biochemistry, 2004;
261(1):143-149 |
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Title
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Biochemical effects of
Citrullus colocynthis in normal and diabetic rat |
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Authors
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Fatma Al-Ghaithi1,
Mamdouh R. El-Ridi1, Ernest Adeghate2,
Mohamed H. Amiri1 |
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Address
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Department of Biology, Faculty of Science, United Arab Emirates
University, Al Ain, UAE; Department of Anatomy, Faculty of Medicine
and Health Science, United Arab Emirates University, Al Ain, UAE |
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Abstract
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Diabetes mellitus is one
of the most common endocrine diseases. In UAE many traditional plants
such as the Citrullus colocynthis (Handal) are used as
antidiabetic remedies. The aim of this study was to examine the effect
of the aqueous extract of the seed of C. colocynthis on the
biochemical parameters of normal and streptozotocin (STZ)-induced
diabetic rats. Diabetes mellitus was induced by a single
intraperitoneal (60 mg/kg body wt1) injection of STZ.
Normal and diabetic rats were fed with the plant extract daily by oral
intubation for 2 weeks. Blood sample were collected at the beginning
and end of the experiment for the measurement of biochemical
parameters. The plasma level of alanine aminotranferase (ALT),
alkaline phosphatase (ALP), aspartate aminotransferase (AST), gamma-glutamyl
transferase (GGT), lactic dehydrogenase (LDH) increased significantly
after the onset of diabetes. Oral administration of the plant extract
reduced the plasma level of AST and LDH significantly. However, the
plant extract failed to reduce the increased blood level of GGT and
ALP in diabetic rats. Blood urea nitrogen (BUN) increased
significantly after the onset of diabetes. No significant difference
was observed in the blood creatinine, K+, Na+,
Ca2+ and P levels of normal and diabetic rats. The plant
extract did not have any effect on BUN level, however, it caused an
increase in the level of K+, Na+ in diabetic
rats. In conclusion, oral administration of the aqueous extract of the
C. colocynthis can ameliorate some of the toxic effects of
streptozotocin. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCc179 |
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Medicinal Plant
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Trigonella
foenum-graecum L. (Leguminosae), Globularia alypum L. (Globulariaceae),
Artemisia herba-alba Asso. (Compositae), Citrullus colocynthis
(L.) Schrad. (Cucurbitaceae) and Tetraclinis articulata Benth.
(Cupressaceae) |
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Plant part(s)
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Aerial parts |
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Objective |
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To study the effect of
plants to treat diabetes in oritenal Morocco |
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Journal Source
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J Ethnopharmacol.
1997; 58(1):45-54 |
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Title
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Phytotherapy of
hypertension and diabetes in oriental Morocco |
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Authors
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Ziyyat A, Legssyer A,
Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W |
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Address
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Department of Biology,
University Mohamed the First, Faculty of Sciences, Oujda, Morocco |
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Abstract
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In order to select the
main medicinal plants used in folk medicine to treat arterial
hypertension and/or diabetes, a survey was undertaken in different
areas of oriental Morocco. The patients (370 women and 256 men) were
divided into three groups: diabetics (61%), hypertensives (23%) and
hypertensive diabetic persons (16%). On average, 67.51% of patients
regularly use medicinal plants. This proportion is perceptibly the
same in all groups and does not depend on sex, age and socio-cultural
level. This result shows that phytotherapy is widely adopted in
northeastern Morocco. For diabetes, 41 plants were cited, of which the
most used were Trigonella foenum-graecum L. (Leguminosae), Globularia
alypum L. (Globulariaceae), Artemisia herba-alba Asso. (Compositae),
Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) and Tetraclinis
articulata Benth. (Cupressaceae). In the hypertension's therapy 18
vegetal species were reported, of which the most used were Allium
sativum L. (Liliaceae), Olea europea L. (Oleaceae), Arbutus unedo L. (Ericaceae),
Urtica dioica L. (Urticaceae) and Petroselinum crispum A.W. Hill (Apiaceae).
Among the 18 species used for hypertension, 14 were also employed for
diabetes. Moreover, these two diseases were associated in 41% of
hypertensives. These findings suggest that hypertension observed in
this region would be in a large part related to diabetes. |
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Diseases |
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Disease Link |
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