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DiaMedBase ID |
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DMPCd182 |
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Medicinal Plant
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Cleome-Droserifolia (C.d.) |
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Plant part(s)
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whole
plant |
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Objective |
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To
study the hypoglycemic effect of the plant Cleome-Droserifolia (C.d.) |
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Journal Source
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Boll Chim Farm.
1996; 135(9):507-517 |
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Title
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Role of the hypoglycemic plant extract
cleome droserifolia in improving glucose and lipid metabolism and its
relation to insulin resistance in fatty liver |
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Authors
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Nicola WG, Ibrahim KM, Mikhail TH, Girgis RB, Khadr ME |
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Address
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Endocrinology Unit, National Research Centre, Giza, Egypt |
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Abstract
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In
this work the mechanism of the hypoglycemic effect of the plant
Cleome-Droserifolia (C.d.) was studied in a group of albino rats
rendered glucose intolerant by tetracycline (T.) induced fatty liver,
and compared with a normal control (C.) rats. The plant extract
significantly suppressed the rise in peripheral blood glucose
concentrations, both in the basal (fasting) state and after glucose
intake. Suppression of basal blood glucose indicated a lowering effect
of the plant extract on hepatic glucose output (HGO). The postprandial
hypoglycemic effect of the plant extract without increasing insulin
secretion was explained by; First: Potentiation of peripheral and
hepatic insulin sensitivity. Second: by diminishing intestinal glucose
absorption, which was evident by blunting plasma glucose levels
throughout the oral glucose challenge. This plant might prove to have
a promising therapeutic value in the treatment of diabetes mellitus,
for besides its postprandial hypoglycemic effect, its suppression to
hepatic glucose output in the fasting state is a beneficial
therapeutic finding in favour of the plant as insulin is the most
important drug that brings about this effect. The plant has also got a
hypocholesterolemic effect more specifically on low density
lipoprotein cholesterol (LDL-C) which consequently raised the high
density lipoprotein cholesterol/low density lipoprotein cholesterol (HDL-C/LDL-C)
ratio. This adds to its value as a protective and antiatherogenic
agent. |
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Diseases |
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Disease Link |
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