|
|
|
|
DiaMedBase ID |
|
DMPCi185 |
|
Medicinal Plant
|
|
Coccinia indica |
|
Plant part(s)
|
|
Leaves |
|
Objective |
|
To study the hypoglycemic
and antihyperglycemic effect of Coccinia indica leaf extract |
|
Journal Source
|
|
Pharmaceutical Biology
(Formerly International Journal of Pharmacognosy),
2002; 40(3):165-170 |
|
Title
|
|
Effect of Coccinia
indica on Blood Glucose, Insulin and Key Hepatic Enzymes in
Experimental Diabetes |
|
Authors
|
|
S. Venkateswaran and L.
Pari |
|
Address
|
|
Not available |
|
Abstract
|
|
Administration of Coccinia
indica leaf extract to normal and streptozotocin diabetic animals
exhibited significant hypoglycemic and antihyperglycemic effect and
reversed biochemical complications. Oral administration of 200mg/ kg
of ethanol extract of Coccinia indica leaves (CLEt) to diabetic
animals for 45 days resulted in a significant reduction in blood
glucose, glycosylated haemoglobin and an increase in total haemoglobin
and plasma insulin. Similarly, the administration of CLEt to normal
animals resulted in a significant hypoglycemic effect. The activities
of hepatic hexokinase, glucose-6-phosphatase,
fructose-1,6-bisphosphatase and glucose-6-phosphate dehydrogenase, a
lipogenic enzyme, were measured in the liver of normal, diabetic,
normal rats separately treated with CLEt and glibenclamide, and
diabetic rats treated separately with CLEt and glibenclamide. The
activities of the lipogenic enzyme and hexokinase were significantly
decreased, whereas the activities of gluconeogenic enzymes were
significantly increased in the diabetic liver. Both CLEt and
glibenclamide were able to restore the altered enzyme activities to
almost control levels. CLEt was more effective than glibenclamide. The
results indicate that the administration of CLEt to diabetic animals
normalizes blood glucose and causes marked improvement of altered
carbohydrate metabolic enzymes during diabetes. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCi186 |
|
Medicinal Plant
|
|
Coccinia indica, Tragia involucrata, G. sylvestre, Pterocarpus
marsupium, Trigonella foenum-graecum, Moringa oleifera, Eugenia
jambolana, Tinospora cordifolia, Swertia chirayita, Momordica
charantia, Ficus glomerata, Ficus benghalensis, Vinca rosea, Premna
integrifolia, Mucuna prurita, Terminalia bellirica, Sesbenia
aegyptiaca, Azadirachta indica, Dendrocalamus hamiltonii, Zingiber
officinale, Aegle marmelos, Cinnamomum tamala, Trichosanthes
cucumerina and Ocimum sanctum |
|
Plant part(s)
|
|
Whole plant |
|
Objective |
|
To
investigate the hypoglycaemic activity of 24 medicinal plants |
|
Journal Source
|
|
J Ethnopharmacol,
2003; 84(1):105-108 |
|
Title
|
|
Comparative evaluation of hypoglycaemic activity of some Indian
medicinal plants in alloxan diabetic rats |
|
Authors
|
|
Kar
A, Choudhary BK, Bandyopadhyay NG |
|
Address
|
|
Satsang Herbal Research and Analytical Laboratories, PO Satsang-814
116 Deoghar, India. pratip_neogy@hotmail.com |
|
Abstract
|
|
In our experiments 30 hypoglycaemic
medicinal plants (known and less known) have been selected for
thorough studies from indigenous folk medicines, Ayurvedic, Unani and
Siddha systems of medicines. In all the experiments with different
herbal samples (vacuum dried 95% ethanolic extracts), definite blood
glucose lowering effect within 2 weeks have been confirmed in alloxan
diabetic albino rats. Blood glucose values are brought down close to
normal fasting level using herbal samples at a dose of 250 mg/kg once,
twice or thrice daily, as needed. While evaluating comparative
hypoglycaemic activity of the experimental herbal samples, significant
blood glucose lowering activities are observed in decreasing order in
the following 24 samples-Coccinia indica, Tragia involucrata, G.
sylvestre, Pterocarpus marsupium, T. foenum-graecum, Moringa oleifera,
Eugenia jambolana, Tinospora cordifolia, Swertia chirayita, Momordica
charantia, Ficus glomerata, Ficus benghalensis, Vinca rosea, Premna
integrifolia, Mucuna prurita, Terminalia bellirica, Sesbenia
aegyptiaca, Azadirachta indica, Dendrocalamus hamiltonii, Zingiber
officinale, Aegle marmelos, Cinnamomum tamala, Trichosanthes
cucumerina and Ocimum sanctum. Present studies besides confirming
hypoglycaemic activities of the experimental herbal samples, help
identify more potent indigenous hypoglycaemic herbs (in crude
ethanolic extract) from the comparative study of the reported
experimental results. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCi187 |
|
Medicinal Plant
|
|
Coccinia indica |
|
Plant part(s)
|
|
Leaves |
|
Objective |
|
To study the antioxidant
effect of an ethanolic extract of Coccinia indica leaves |
|
Journal Source
|
|
Journal of Ethnopharmacology
2003; 84:163-168 |
|
Title
|
|
Effect of Coccinia indica leaves on antioxidant
status in streptozotocin-induced diabetic rats |
|
Authors
|
|
S. Venkateswaran, L. Pari |
|
Address
|
|
Department of Biochemistry, Faculty of Science,
Annamalai University, Annamalainagar-608 002, Chidambaram, Tamil Nadu,
India |
|
Abstract
|
|
The antioxidant effect of an ethanolic extract of
Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine
in India, was studied in Streptozotocin-diabetic rats. Oral
administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body
weight) for 45 days resulted in a significant reduction in
thiobarbituric acid reactive substances and hydroperoxides. The
extract also causes a significant increase in reduced glutathione,
superoxide dismutase, catalase, glutathione peroxidase and
glutathione-S-transferase in liver and kidney of streptozotocin
diabetic rats, which clearly shows the antioxidant property of CLEt.
The effect of CLEt at 200 mg/kg body weight was more effective than
glibenclamide. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCi188 |
|
Medicinal Plant
|
|
Coccinia indica |
|
Plant part(s)
|
|
Leaves |
|
Objective |
|
To
test the glucose tolerance levels in diabetic patients from leaves of
the plant |
|
Journal Source
|
|
Bangladesh Med Res
Counc Bull,
1979; 5(2):60-66 |
|
Title
|
|
Coccinia indica in the treatment of patients with diabetes mellitus |
|
Authors
|
|
Azad
Khan AK, Akhtar S, Mahtab H |
|
Address
|
|
--- |
|
Abstract
|
|
Coccinia indica is a creeper which grows wildly in Bangladesh and in
many parts of the Indian sub-continent. The plant has been used since
ancient times as an antidiabetic drug by physicians who practice the
Indian system of medicine known as Ayurvedha. We have conducted a
double blind control trial with preparation from the leaves of the
plant on uncontrolled, maturity onset diabetics. The trial lasted for
six weeks for an individual patient. Out of the 16 patients who
received the experimental preparations 10 showed marked improvement in
their glucose tolerance while none out of the 16 patients in the dummy
group showed such a marked improvement. This difference is highly
significant (kappa 2 with Yates' correction = 11.7, P < 0.001). |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCi189 |
|
Medicinal Plant
|
|
Coccinia indica |
|
Plant part(s)
|
|
Not available |
|
Objective |
|
To
study the anti-diabetic activity of Coccinia indica |
|
Journal Source
|
|
Indian J Med Sci.,
1985; 39(2):27-29 |
|
Title
|
|
A
study on the anti-diabetic activity of Coccinia indica in dogs |
|
Authors
|
|
Singh
N, Singh SP, Vrat S, Misra N, Dixit KS, Kohli RP |
|
Address
|
|
Not
available |
|
Abstract
|
|
Not
available |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPCi190 |
|
Medicinal Plant
|
|
Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo
Linn, Benincasa hispida Thunb Cogn, Trichosanthes anguina Nees,
Momordica charantia Linn and Coccinia indica |
|
Plant part(s)
|
|
Whole
plant |
|
Objective |
|
To
study the blood sugar lowering efficacy of eight plants of
Cucurbitaceae family |
|
Journal Source
|
|
Indian J Med Res.,
1989; 90:300-305 |
|
Title
|
|
Blood sugar lowering potentiality of selected Cucurbitaceae plants of
Indian origin |
|
Authors
|
|
Chandrasekar B, Mukherjee B, Mukherjee SK |
|
Address
|
|
Not
available |
|
Abstract
|
|
Using five experimental
models, the blood sugar lowering efficacy of eight plants of
Cucurbitaceae family has been assessed. The ethanolic extract of
Cucumis sativus Linn, Cucumis melo utilissimum Roxb, Cucumis melo
Linn, Benincasa hispida Thunb Cogn and Tricosanthes anguina Nees, when
administered in 250 mg/kg dose, orally to rats failed to lower blood
sugar or to depress the peak value, after glucose load. However,
ethanolic extract of Momordica charantia Linn plant and Coccinia
indica Whit and Arn root significantly lowered blood sugar in fasted
model and depressed the peak value in glucose loaded model. Ethanolic
extract of Tricosanthes dioica Roxb plant caused a significant
lowering of blood sugar in fasted rats and depressed the peak value in
glucose loaded single and longterm fed groups of rats. The ethanolic
extract of the aerial part of T. dioica also induced significant
depression in the peak values in the glucose loaded models. |
|
Diseases |
|
Disease Link |
|
