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DiaMedBase ID |
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DMPCp191 |
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Medicinal Plant
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Cogniauxia podoleana
Baillon |
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Plant part(s)
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Leaves |
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Objective |
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To investigate the
hypoglycemic activity in normal and alloxan diabetic rats |
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Journal Source
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J Ethnopharmacol,
2004; 92(2-3):229-232 |
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Title
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Hypoglycemic and antihyperglycemic effects of diethyl ether fraction
isolated from the aqueous extract of the leaves of Cogniauxia
podoleana Baillon in normal and alloxan-induced diabetic rats |
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Authors
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Diatewa M, Samba CB, Assah TC, Abena AA |
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Address
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Laboratoire de Biochimie et
Pharmacologie, Faculte des Sciences de la Sante, Universite Marien
NGOUABI, B.P. 69, Brazzaville, Congo. diatewamartin@yahoo.fr |
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Abstract
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Cogniauxia podoleana Baillon (Cucurbitaceae family) leaves are used in
Congolese traditional medicine for the treatment of diabetes mellitus.
Based on an increasing number of reports on blood glucose level
reduction associated with some saponins and flavonoids isolated from
medicinal plants, the hypoglycemic and antihyperglycemic effects of
flavonoid and saponin fractions were investigated. Saponin fractions
were obtained by the fractionation of aqueous extract of leaves using
benzene and ethyl acetate. Flavonoid fraction was isolated from the
aqueous phase obtained after the settling of benzene-aqueous extract
mixture by means of diethyl ether. The diethyl ether fraction
(100mg/kg) reduced the blood glucose levels in 40.0% 3h after oral
administration to normal rats. In contrast, the oral administration of
benzene and ethyl acetate fractions at a dose of 100mg/kg to normal
rats did not decrease the blood glucose levels. The diethyl ether
fraction at a dose of 50mg/kg was found to reduce the increase of
blood glucose levels in 29.4 and 44.5%, respectively, 3 and 4h after
oral administration to alloxan-induced diabetic rats, whereas at a
dose of 100mg/kg, it decreased the levels of hyperglycemia in 41.4 and
70.4%, respectively, after 3 and 4h. These data confirm the
antidiabetic activity of the leaves of Cogniauxia podoleana Baillon in
Congolese traditional medicine for diabetes mellitus treatment.
However, it was important to note that the antihyperglycemic action
could not be attributed to the presence of flavonoids; contamination
is detected (amino acids, carbohydrates and other compounds) in the
diethyl ether fraction containing flavonoids. |
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Diseases |
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Disease Link |
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