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DiaMedBase ID
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DMPCc193 |
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Medicinal Plant
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Commelina communis |
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Plant part(s)
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Whole plant |
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Objective
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To study the potent
inhibitory activity against alpha-glucosidase |
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Journal Source
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Planta Med.
1999; 65(5):437-439 |
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Title
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alpha-Glucosidase
inhibitors from Commelina communis |
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Authors
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Kim HS, Kim YH, Hong YS,
Paek NS, Lee HS, Kim TH, Kim KW, Lee JJ |
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Address
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Not available |
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Abstract
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A methanolic extract of
Commelina communis showed potent inhibitory activity against alpha-glucosidase.
One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine
(DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2),
1-deoxynojirimycin (3), alpha-homonojirimycin (4) and
7-O-beta-D-glucopyranosyl alpha-homonojirimycin (5) were isolated by
bioassay-directed fractionation and separation. These compounds have
been identified for the first time from Commelina communis, supporting
the pharmacological basis of this plant that has been used as a
traditional herbal medicine for the treatment of diabetes. |
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Diseases |
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Disease Link |
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