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DiaMedBase ID |
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DMPCf202 |
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Medicinal Plant
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Coscinium fenestratum
Colebr |
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Plant part(s)
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Stems |
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Objective |
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To
investigate the effect of stem extract on the treatment of diabetes
mellitus |
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Journal Source
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J Ethnopharmacol,
2005;
97(2):369-374 |
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Title
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Antidiabetic activity of alcoholic stem
extract of Coscinium fenestratum in streptozotocin-nicotinamide
induced type 2 diabetic rats |
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Authors
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Shirwaikar A, Rajendran K, Punitha IS |
|
Address
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Department of Pharmacognosy, Manipal College of Pharmaceutical
Sciences, Manipal 576 104, India. annieshirwaikar@yahoo.com |
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Abstract
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The antidiabetic potential of the
alcoholic stem extract of Coscinium fenestratum Colebr. (Menispermaceae),
a medicinal plant widely used in the traditional Ayurveda and Siddha
systems of medicine for the treatment of diabetes mellitus was
evaluated in the STZ-nicotinamide induced type 2 diabetic model.
Graded doses of the alcoholic stem extract were administered to normal
and experimental diabetic rats for 12 days. Significant (p < 0.05)
reduction in fasting blood glucose levels were observed in the normal
as well as in the treated diabetic animals. Serum insulin levels were
not stimulated in the animals treated with the extract. In addition,
changes in body weight, serum lipid profiles, thiobarbituric acid
reactive substance levels, glycosylated hemoglobin and liver glycogen
levels assessed in the extract treated diabetic rats were compared
with diabetic control and normal animals. Significant results were
observed in the estimated parameters, thereby justifying the use of
the plant in the indigenous system of medicine. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
|
DMPCf203 |
|
Medicinal Plant
|
|
Coscinium fenestratum |
|
Plant part(s)
|
|
Stems |
|
Objective |
|
To study the alcoholic
extract of stems of Coscinium fenestratum on carbohydrate metabolism
and antioxidant status in streptozotocin-nicotinamide induced type 2
diabetic rats |
|
Journal Source
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Evid Based Complement Alternat Med.
2005; 2(3):375-381 |
|
Title
|
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Alcoholic stem extract
of Coscinium fenestratum regulates carbohydrate metabolism and
improves antioxidant status in streptozotocin-nicotinamide induced
diabetic rats |
|
Authors
|
|
Punitha IS, Rajendran K,
Shirwaikar A, Shirwaikar A |
|
Address
|
|
Department of
Pharmacognosy, Manipal College of Pharmaceutical Sciences Manipal
576104, India |
|
Abstract
|
|
Alcoholic extract of the
stems of Coscinium fenestratum, a medicinal plant indigenous to India
and Sri Lanka used in ayurveda and siddha medicine for treating
diabetes, was studied for its carbohydrate metabolism effect and
antioxidant status in streptozotocin-nicotinamide induced type 2
diabetic rats. Oral administration of C. fenestratum stem extract in
graded doses caused a significant increase in enzymatic antioxidants
such as catalase, superoxide dismutase, glutathione synthetase,
peroxidase, and glutathione peroxidase and in the nonenzymatic
antioxidants ascorbic acid, ceruloplasmin and tocopherol. Effects of
alcoholic extract on glycolytic enzymes such as glucose-6-phosphate
dehydrogenase, lactate dehydrogenase and hexokinase showed a
significant increase in their levels, whereas a significant decrease
was observed in the levels of gluconeogenic enzyme,
glucose-6-phosphatase and alanine aminotransferase in treated diabetic
rats. Serum creatinine and urea levels also declined significantly.
This investigation demonstrates significant antidiabetic activity of
C. fenestratum. |
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Diseases |
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Disease Link |
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