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DiaMedBase ID
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DMPCc207 |
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Medicinal Plant
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Croton cajucara |
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Plant part(s)
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Barks |
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Objective
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To study hypoglycemic
activity in alloxan-induced diabetic rats |
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Journal Source
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Planta Med.
1997; 63(6):558-560 |
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Title
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Hypoglycemic effect of
trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara |
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Authors
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Farias RA, Rao VS, Viana
GS, Silveira ER, Maciel MA, Pinto AC |
|
Address
|
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Departamento de Fisiologia
e Farmacologia, Universidade Federal do Ceara, Brasil |
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Abstract
|
|
trans-Dehydrocrotonin (t-DCTN),
a 19-nor-clerodane diterpene isolated from the bark of Croton cajucara
Benth. (Euphorbiaceae) demonstrated a significant hypoglycemic
activity in alloxan-induced diabetic rats but not in normal rats, at
oral doses of 25 and 50 mg/kg body weight. The drug also effectively
lowered the blood sugar levels in glucose fed normal rats. The
hypoglycemic effect of t-DCTN was almost comparable to that produced
by glibenclamide (2 mg/kg), a clinically useful drug. The results
indicate the antihyperglycemic potential of t-DCTN. |
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Diseases |
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Disease Link |
