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DiaMedBase ID |
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DMPCf212 |
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Medicinal Plant
|
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Cucurbita
ficifolia, Guaiacum coulteri, Lepechinia caulescens, and Psacalium
peltatum |
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Plant part(s)
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Whole
plant |
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Objective |
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to
study the Hypoglycemic activity of some antidiabetic plants |
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Journal Source
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Arch Med Res.
1992; 23(3):105-109 |
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Title
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Hypoglycemic activity
of some antidiabetic plants |
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Authors
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Roman
Ramos R, Lara Lemus A, Alarcon Aguilar F, Flores Saenz JL |
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Address
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Health Science Department, Biological and Health Sciences Division,
Metropolitan Autonomous University, Iztapalapa Campus, Mexico, D.F |
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Abstract
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To
assess the hypoglycemic activity mechanism of some plants used
empirically by the Mexican population as antidiabetics, traditional
preparations of Cucurbita ficifolia, Guaiacum coulteri, Lepechinia
caulescens, and Psacalium peltatum, water, tolbutamide, and Regular
Insulin were administered to three groups of rabbits each: 1. Healthy
rabbits with temporary hyperglycemia induced by the subcutaneous
administration of glucose. 2. Rabbits with moderate diabetes (fasting
glycemia 150-300 mg/dl), induced with alloxan. 3. Rabbits with severe
diabetes (fasting glycemia higher than 400 mg/dl), induced with
alloxan. The plant preparations had a hypoglycemic effect similar to
tolbutamide in healthy and mild diabetic rabbits and had no effect in
severely diabetic rabbits. These results suggest that some pancreatic
function or the presence of insulin is required for the hypoglycemic
activity of these plants. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCf213 |
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Medicinal Plant
|
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Cucurbita
ficifolia, Phaseolus vulgaris, Opuntia streptacantha, Spinacea
oleracea, Cucumis sativus,
Cuminum cyminum, Brassica oleracea var. botrytis, Allium cepa, Allium
sativum, Psidium guajava, Brassica oleracea and Lactuca sativa var.
romana |
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Plant part(s)
|
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Whole plant |
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Objective |
|
To study the anti-hyperglycemic effect of 12 edible
plants |
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Journal Source
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Journal of Ethnopharmacology
1995; 48:25-32 |
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Title
|
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Anti-hyperglycemic effect of some edible plants |
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Authors
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R. Roman-Ramos, J.L. Flores-Saenz, F.J. Alarcon-Aguilar |
|
Address
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Department of Health Sciences, Division of Biological
and Health Sciences, Metropolitan Autonomous University, lztapalapa
Campus. Mexico, D.F., Apdo. Postal 55-535, Mexico |
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Abstract
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The
anti-hyperglycemic effect of 12 edible plants was studied on 27
healthy rabbits, submitted weekly to subcutaneous glucose tolerance
tests after gastric administration of water, tolbutamide or a
traditional preparation of the plant. Tolbutamide, Cucurbita
ficifolia, Phaseolus vulgaris, Opuntia streptacantha, Spinacea
oleracea, Cucumis sativus and Cuminum cyminum decrease
significantly the area under the glucose tolerance curve and the
hyperglycemic peak.
Brassica oleracea var.
botrytis, Allium cepa and Allium sativum only decrease the
hyperglycemic peak. The glycemic decreases caused by Psidium
guajava, Brassica oleracea and Lactuca sativa var.
romana were not significant (p > 0.05). The integration of a menu
that includes the edible plants with hypoglycemic activity for the
control and prevention of diabetes mellitus may be possible and
recommendable. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCf214 |
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Medicinal Plant
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Cucurbita ficifolia |
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Plant part(s)
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|
Fruits |
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Objective |
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To study the acute
hypoglycemic effects of freeze-dried juice of Cucurbita ficifolia |
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Journal Source
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Journal of Ethnopharmacology
2002; 82:185-189 |
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Title
|
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Evaluation of the hypoglycemic effect of Cucurbita
ficifolia BoucheŽ (Cucurbitaceae) in different experimental models |
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Authors
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F.J. Alarcon-Aguilar
a,
E. Hernandez-Galicia a,
A.E. Campos-Sepulveda b,
S. Xolalpa-Molina c,
J.F. Rivas-Vilchis a,
L.I. Vazquez-Carrillo a,
R. Roman-Ramos a |
|
Address
|
|
a DivisioŽn de Ciencias BioloŽgicas y de la Salud,
Universidad AutoŽnoma Metropolitana, Unidad Iztapalapa, Apdo. P.
55-535, 09340 Mexico, D.F., Mexico b Departamento de FarmacologęŽa,
Ciudad Universitaria, UNAM, Mexico, D.F., Mexico c Herbario IMSS-M,
Centro MeŽdico Nacional Siglo XXI, Subjefatura de InvestigacioŽn, IMSS,
Mexico, D.F., Mexico |
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Abstract
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|
Acute hypoglycemic effects of freeze-dried juice of
Cucurbita ficifolia BoucheŽ (Cucurbitaceae) fruits were studied in
healthy and alloxan-diabetic mice. C. ficifolia fruit administered by
intraperitoneal route produced, in a dose-dependent manner, a
significant decrease of the glycemia in healthy mice. Although oral
route of C. ficifolia fruit juice also caused significant reductions
of blood glucose levels in healthy mice, the effect was minor. The
juice administered by intraperitoneal route showed an acute
hypoglycemic effect in alloxan-diabetic mice. In addition, daily oral
administration of this preparation showed a highly significant
reduction of the glycemia after 14 days of treatment. Freeze- dried
juice caused acute toxicity when administered intraperitoneally, and
also when it was administered daily by the oral route. |
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Diseases |
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Disease Link |
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