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DiaMedBase ID |
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DMPCc215 |
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Medicinal Plant
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Trigonella foenum-graecum,
Cinnamomun zeylanicum (cinnamon), Cuminum cyminum (cumin),
Origanum syriacum (oregano) |
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Plant part(s)
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Leaves |
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Objective |
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To
study the ability of various combinations of
essential oils such as fenugreek, cinnamon, cumin, oregano, etc. to
enhance insulin sensitivity |
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Journal Source
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Diabetes, Obesity and Metabolism
2005; 7(2):193 |
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Title
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Effects of a novel
formulation of essential oils on glucose– insulin metabolism in
diabetic and hypertensive rats: a pilot study |
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Authors
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N. Talpur1,
B. Echard1 C. Ingram2,
D. Bagchi3 and H. Preuss1
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Address
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1Department
of Physiology and Biophysics, Georgetown University Medical Center,
Washington, DC, USA
2North American Herb and Spice Waukegan, IL,
USA
3Department of Pharmacy
Sciences, Creighton University School of Pharmacy and AHP, Omaha, NE,
USA |
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Abstract
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Background: Insulin
resistance and its most severe form type 2 diabetes mellitus are
rapidly increasing throughout the world. It is generally recognized
that natural products with a long history of safety can increase
insulin sensitivity. Aims: The present investigation examined the
ability of various combinations of essential oils such as fenugreek,
cinnamon, cumin, oregano, etc. to enhance insulin sensitivity. As a
first approximation, we examined the effects of these natural products
on Zucker fatty rats (ZFRs), a model of obesity and insulin
resistance, and spontaneously hypertensive rats (SHRs), a model of
genetic hypertension. Material and Methods: Water or essential oils
were given orally via droplets, and insulin sensitivity was estimated
by systolic blood pressure (SBP) changes and circulating glucose
and/or insulin concentrations. Results: We have found that the ability
to alter SBP in rat models is the most sensitive early index of
insulin sensitivity. The combined essential oils lowered circulating
glucose levels and SBP in both ZFRs and SHRs, suggesting that these
natural products are enhancing insulin sensitivity. The second series
of studies examined two additional combinations of essential oils
along with the original formula. The major differences were in the
types and proportions of individual oils contributing to a given
formula. Conclusions: Although all the three formulae decreased SBP in
ZFRs, one of the formulae was more effective than the others in
lowering circulating glucose in the glucose tolerance testing.
Accordingly, some essential oils may be added to the long list of
natural products that can affect insulin sensitivity. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCn216 |
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Medicinal Plant
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Cuminum nigrum |
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Plant part(s)
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|
Seeds |
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Objective |
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To
study the hypoglycaemic activity |
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Journal Source
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Planta
Med.,
1985; (2):81-85 |
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Title
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Study of hypoglycaemic activity of Cuminum nigrum seeds in normal and
alloxan diabetic rabbits |
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Authors
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Akhtar MS, Ali MR |
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Address
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Not
available |
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Abstract
|
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Not
available |
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Diseases |
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Disease Link |
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DiaMedBase ID |
|
DMPCn217 |
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Medicinal Plant
|
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Cuminum nigrum |
|
Plant part(s)
|
|
Seeds |
|
Objective |
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To study the Hypoglycemic
activity in normal and alloxan diabetic rabbits |
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Journal Source
|
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Planta Med.
1985; (2):281-285 |
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Title
|
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Study of hypoglycaemic
activity of Cuminum nigrum seeds in normal and alloxan diabetic
rabbits |
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Authors
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Akhtar MS, Ali MR |
|
Address
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Not available |
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Abstract
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Not available |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCc218 |
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Medicinal Plant
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Cucurbita ficifolia,
Phaseolus vulgaris, Opuntia streptacantha, Spinacea oleracea, Cucumis
sativus,
Cuminum
cyminum, Brassica oleracea var. botrytis, Allium cepa, Allium
sativum, Psidium guajava, Brassica oleracea and Lactuca sativa var.
romana |
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Plant part(s)
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Whole plant |
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Objective |
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To study the anti-hyperglycemic effect of 12 edible
plants |
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Journal Source
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Journal of Ethnopharmacology
1995; 48:25-32 |
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Title
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Anti-hyperglycemic effect of some edible plants |
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Authors
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R. Roman-Ramos, J.L. Flores-Saenz, F.J. Alarcon-Aguilar |
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Address
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Department of Health Sciences, Division of Biological
and Health Sciences, Metropolitan Autonomous University, lztapalapa
Campus. Mexico, D.F., Apdo. Postal 55-535, Mexico |
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Abstract
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The
anti-hyperglycemic effect of 12 edible plants was studied on 27
healthy rabbits, submitted weekly to subcutaneous glucose tolerance
tests after gastric administration of water, tolbutamide or a
traditional preparation of the plant. Tolbutamide, Cucurbita
ficifolia, Phaseolus vulgaris, Opuntia streptacantha, Spinacea
oleracea, Cucumis sativus and Cuminum cyminum decrease
significantly the area under the glucose tolerance curve and the
hyperglycemic peak.
Brassica oleracea var.
botrytis, Allium cepa and Allium sativum only decrease the
hyperglycemic peak. The glycemic decreases caused by Psidium
guajava, Brassica oleracea and Lactuca sativa var.
romana were not significant (p > 0.05). The integration of a menu
that includes the edible plants with hypoglycemic activity for the
control and prevention of diabetes mellitus may be possible and
recommendable. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCn219 |
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Medicinal Plant
|
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Cuminum nigrum |
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Plant part(s)
|
|
Seeds |
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Objective |
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To study the hypoglycaemic
effect of seeds on blood glucose levels |
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Journal Source
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Phytotherapy Research,
2000; 14(2):103-106 |
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Title
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Hypoglycaemic action of
the flavonoid fraction of Cuminum nigrum seeds |
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Authors
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Mushtaq Ahmad
1, M. Shoaib Akhtar
2, Tahira Malik
3, Anwar H. Gilani
4 |
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Address
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1Department
of Pharmacology, Quaid-e-Azam Medical College, Bahawalpur, Pakistan
2Department of
Physiology and Pharmacology, University of Agriculture, Faisalabad,
38040, Pakistan 3Department
of Pharmacology, Postgraduate Medical Institute, Lahore, Pakistan
4Department of
Physiology and Pharmacology, The Aga Khan University, Karachi,
Pakistan |
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Abstract
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The seeds of Cuminum
nigrum were screened phytochemically and were found to contain 8%
flavonoids and 0.01% alkaloids. When studied for their effect on blood
glucose levels, oral administration of the flavonoid contents of the
plant caused a hypoglycaemic effect at a dose range of 0.5 to
1.5 g/kg, both in normal and alloxan-diabetic rabbits. The
hypoglycaemic effect started 2 h after drug administration, reaching a
maximum within 4-8 h and the blood glucose levels returned close to
normal within 24 h of drug administration. The glibenclamide
(5 mg/kg), produced a hypoglycaemic effect in the normal rabbits,
whereas it had no effect on the blood glucose levels of alloxan-diabetic
rabbits. The alkaloids isolated from C. nigrum seeds, however,
failed to exert any significant hypoglycaemic effect in either the
normal or diabetic rabbits. A 7 day acute toxicity study in rabbits
did not produce any apparent adverse effect at doses as high as 5 g/kg
orally. These data indicate that the total flavonoid contents of C.
nigrum seeds exhibited considerable hypoglycaemic activity in
rabbits and may therefore be responsible for the previously reported
antidiabetic activity of the seeds. Furthermore, it is conceivable
that the C. nigrum flavonoids possess insulin triggering and/or
insulin-like properties. |
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Diseases |
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Disease Link |
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