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DiaMedBase ID |
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DMPCl220 |
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Medicinal Plant
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Momordica charantia, Melia azadirachta, Pterocarpus marsupium,
Tinospora cordifolia , Gymnema sylvestre, Enicostemma littorale,
Emblica officinalis, Eugenia jambolana, Cassia auriculata and
Curcuma longa |
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Plant part(s)
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Whole plant
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Objective |
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To
investigate the antihyperglycaemic and antioxidant activity in STZ-induced
diabetic rats |
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Journal Source
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J Pharm Pharmacol,
2004; 56(11):1435-1442 |
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Title
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Antihyperglycaemic and antioxidant
effect of hyponidd, an ayurvedic herbomineral formulation in
streptozotocin-induced diabetic rats |
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Authors
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Babu
PS, Stanely Mainzen Prince P |
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Address
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Department of Biochemistry, Annamalai
University, Annamalai Nagar-608 002, Tamil Nadu, India |
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Abstract
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Hyponidd is a herbomineral formulation
composed of the extracts of ten medicinal plants ( Momordica charantia,
Melia azadirachta, Pterocarpus marsupium, Tinospora cordifolia ,
Gymnema sylvestre, Enicostemma littorale, Emblica officinalis, Eugenia
jambolana, Cassia auriculata and Curcuma longa). We have investigated
hyponidd for its possible antihyperglycaemic and antioxidant effect in
diabetic rats. Rats were rendered diabetic by streptozotocin (STZ) (45
mg kg(-1) body weight). Oral administration of hyponidd (100 mg kg(-1)
and 200 mg kg(-1)) for 45 days resulted in significant lowered levels
of blood glucose and significant increased levels of hepatic glycogen
and total haemoglobin. An oral glucose tolerance test was also
performed in experimental diabetic rats in which there was a
significant improvement in blood glucose tolerance in the rats treated
with hyponidd. Hyponidd administration also decreased levels of
glycosylated haemoglobin, plasma thiobarbituric acid reactive
substances, hydroperoxides, ceruloplasmin and alpha-tocopherol in
diabetic rats. Plasma reduced glutathione and vitamin C were
significantly elevated by oral administration of hyponidd. The effect
of hyponidd at a dose of 200 mg kg(-1) was more effective than
glibenclamide (600 microg kg(-1)) in restoring the values to near
normal. The results showed that hyponidd exhibits antihyperglycaemic
and antioxidant activity in STZ-induced diabetic rats. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPCl221 |
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Medicinal Plant
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Gymnema sylvestre, Eugenia jambolana, Momordica charantia, Azadirachta
indica, Cassia auriculata, Aegle marmelose, Withania somnifera and
Curcuma longa |
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Plant part(s)
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Leaves |
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Objective |
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To
study the hypoglycemic activity in normal and streptozotocin induced
diabetic mice |
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Journal Source
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Phytother,
2005; 19(5):409-415 |
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Title
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Effect of Dianex, a herbal formulation
on experimentally induced diabetes mellitus |
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Authors
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Mutalik S, Chetana M, Sulochana B, Devi PU, Udupa N |
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Address
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College of Pharmaceutical Sciences, Manipal, Karnataka, India. |
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Abstract
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Dianex, a polyherbal formulation consisting of the aqueous extracts of
Gymnema sylvestre, Eugenia jambolana, Momordica charantia Azadirachta
indica, Cassia auriculata, Aegle marmelose, Withania somnifera and
Curcuma longa was screened for hypoglycemic activity in normal and
streptozotocin induced diabetic mice. Dianex was administered in
different doses of 100-500 mg/kg/day orally in acute (6 h) and
long-term (6 weeks) studies. Blood glucose levels were checked 2-6 h
after treatment in acute studies and every 2 weeks in long-term
studies. Body weight was recorded on the first and final day of the
treatment in the long-term studies with diabetic mice. After 6 weeks,
high-density lipoprotein, triglycerides, total cholesterol, alanine
transaminase (ALT), aspertate transaminase (AST), urea and creatinine
were estimated in serum of the diabetic mice. Glycogen and total
protein levels were estimated in the liver. Also, the liver and
pancreas was subjected to histological examination. Oral glucose
tolerance and in vitro free radical scavenging activity was also
studied.Dianex produced significant (p<0.05) hypoglycemic activity at
250-500 mg/kg doses in both normal and diabetic mice in acute and
long-term studies. The body weight of diabetic mice significantly
(p<0.05) increased with all tested doses of Dianex. The elevated
triglycerides, cholesterol, ALT, AST, urea and creatinine levels in
diabetic mice were significantly (p<0.05) reduced at the doses of 250
and 500 mg/kg. The liver glycogen and protein levels were both
significantly (p<0.05) increased in diabetic mice at 250 and 500 mg/kg
doses. Dianex increased the glucose tolerance significantly (p<0.05)
in both normal and diabetic mice at all the doses tested.
Histopathological examination showed that the formulation decreased
streptozotocin induced injury to the tissues at all the doses tested.
It produced significant (p<0.05) free radical scavenging activity
against ABTS+, DPPH and hydroxyl free radicals at the concentrations
ranging between 10-1000 microg/ml.Thus, in the present study, Dianex
produced significant hypoglycemic activity in both normal and diabetic
animals. It also reversed other diabetic complications in diabetic
mice at 250 and 500 mg/kg doses. In our earlier study, Dianex was well
tolerated in laboratory animals at higher doses (upto 10 g/kg in mice,
acute toxicity; up to 2.5 g/kg in rats, subacute toxicity studies for
30 days) without exhibiting any toxic manifestation. Hence, Dianex may
be useful in the treatment of diabetes mellitus. |
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Diseases |
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Disease Link |
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