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DiaMedBase ID |
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DMPAm001 |
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Medicinal Plant
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Abelmoschus
moschatus |
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Plant part(s)
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Aerial parts |
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Objective |
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To investigate
antihyperglycemic action of myricetin, purified from the aerial part
of Abelmoschus moschatus |
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Journal Source
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Planta Med.
2005; 71(7):617-621 |
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Title
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Myricetin as the active
principle of Abelmoschus moschatus to lower plasma glucose in
streptozotocin-induced diabetic rats |
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Authors
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Liu IM, Liou SS, Lan TW,
Hsu FL, Cheng JT |
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Address
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Department of Pharmacy,
Tajen Institute of Technology, Yen-Pou, Ping Tung Shien, Taiwan, R.O.C.
iml@ccsun.tajen.edu.tw |
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Abstract
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The antihyperglycemic
action of myricetin, purified from the aerial part of Abelmoschus
moschatus (Malvaceae), was investigated in streptozotocin-induced
diabetic rats (STZ-diabetic rats). Bolus intravenous injection of
myricetin decreased the plasma glucose concentrations in a
dose-dependent manner in STZ-diabetic rats. Myricetin at the effective
dose (1.0 mg/kg) significantly attenuated the increase of plasma
glucose induced by an intravenous glucose challenge test in normal
rats. A stimulatory effect of myricetin on glucose uptake of the
soleus muscles isolated from STZ-diabetic rats was obtained in a
concentration-dependent manner from 0.01 to 10.0 micromol/L. The
increase of glucose utilization by myricetin was further characterized
using the enhancement of glycogen synthesis in isolated hepatocytes of
STZ-diabetic rats. These results suggest that myricetin has an ability
to enhance glucose utilization to lower plasma glucose in diabetic
rats lacking insulin. |
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Diseases |
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Disease Link |
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