To investigate the Achyrocline satureioides extract on lowering blood glucose levels

Achyrofuran, a new antihyperglycemic dibenzofuran from the South American medicinal plant Achyrocline satureioides

Shaman Pharmaceuticals, Inc., 213 East Grand Avenue, South San Francisco, California 94080, USA. carney@kosan.com

A new prenylated dibenzofuran, achyrofuran (2), was isolated from an extract of Achyrocline satureioides by bioassay-guided fractionation using the db/db mouse model for type 2 diabetes. Compound 2 significantly lowered blood glucose levels in this model when administered orally at 20 mg/kg q.d.