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DiaMedBase ID |
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DMPAp011 |
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Medicinal Plant
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Acosmium panamense (Fabaceae) |
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Plant part(s)
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Bark |
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Objective |
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To study the hypoglycemic effects of
water and butanolic extracts prepared from the bark of Acosmium
panamense |
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Journal Source
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Journal of Ethnopharmacology
2004; 90:217-220 |
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Title
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Hypoglycemic effect of Acosmium panamense
bark on streptozotocin diabetic rats |
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Authors
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Adolfo Andrade-Cetto
a,
Helmut Wiedenfeld b |
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Address
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a Departamento de Biolog´ıa
Celular, Fac. Ciencias, Universidad Nacional Autónoma de México,
School of Science of Mexico, UNAM, Apartado Postal 70-359, Coyoacan
04510, Mexico b Pharmaceutical Institute, University of
Bonn, An der Immenburg 4, D-53121 Bonn, Germany |
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Abstract
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The hypoglycemic effects of water and
butanolic extracts prepared from the bark of Acosmium panamense (Fabaceae)
were studied in diabetic rats (streptozotocin (STZ)-induced). Oral
application of water extracts at doses of 20 and 200 mg/kg and of
butanol extracts at doses of 20 and 100 mg/kg significantly lowered
the plasma glucose levels in diabetic rats within 3 h. Glibenclamide
was used as reference and showed similar hypoglycemic effect like the
extracts. Three structurally new compounds were isolated from the
plant and shown to be the main constituents in both extracts. |
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Diseases |
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Disease Link |
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