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DiaMedBase ID |
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DMPAb024 |
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Medicinal Plant
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Burdock
(Arctium lappa), cashew (Anacardium occidentale), dandelion (Taraxacum
officinale), elder (Sambucus nigra), fenugreek (Trigonella
foenum-graecum), guayusa (Ilex guayusa), hop (Humulus lupulus), nettle
(Urtica dioica), cultivated mushroom (Agaricus bisporus),
periwinkle (Catharanthus roseus), sage (Salvia officinale), and wild
carrot (Daucus carrota) |
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Plant part(s)
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Whole plant |
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Objective |
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To study the
glycemic effect |
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Journal Source
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Diabetes Res.,
1989; 10(2):69-73 |
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Title
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Glycaemic
effects of traditional European plant treatments for diabetes. Studies
in normal and streptozotocin diabetic mice |
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Authors
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Swanston-Flatt SK,
Day C, Flatt PR, Gould BJ, Bailey CJ |
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Address
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Department of
Biochemistry, University of Surrey, Guildford, UK |
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Abstract
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Twelve plants used for the traditional
treatment of diabetes mellitus in northern Europe were studied using
normal and streptozotocin diabetic mice to evaluate effects on glucose
homeostasis. The plants were administered in the diet (6.25% by
weight) and/or as decoctions or infusions in place of drinking water,
to coincide with the traditional method of preparation. Treatment for
28 days with preparations of burdock (Arctium lappa), cashew
(Anacardium occidentale), dandelion (Taraxacum officinale), elder (Sambucus
nigra), fenugreek (Trigonella foenum-graecum), guayusa (Ilex guayusa),
hop (Humulus lupulus), nettle (Urtica dioica), cultivated mushroom
(Agaricus bisporus), periwinkle (Catharanthus roseus), sage (Salvia
officinale), and wild carrot (Daucus carrota) did not affect the
parameters of glucose homeostasis examined in normal mice (basal
plasma glucose and insulin, glucose tolerance, insulin-induced
hypoglycaemia and glycated haemoglobin). After administration of
streptozotocin (200 mg/kg) burdock and nettle aggravated the diabetic
condition, while cashew, dandelion, elder, fenugreek, hop, periwinkle,
sage and wild carrot did not significantly affect the parameters of
glucose homeostasis studied (basal glucose and insulin,
insulin-induced hypoglycaemia, glycated haemoglobin and pancreatic
insulin concentration). Guayusa and mushroom retarded the development
of hyperglycaemia in streptozotocin diabetes and reduced the
hyperphagia, polydipsia, body weight loss, and glycated haemoglobin.
Mushroom also countered the initial reduction in plasma insulin and
the reduction in pancreatic insulin concentration, and improved the
hypoglycaemic effect of exogenous insulin. These studies suggest the
presence of potentially useful antidiabetic agents in guayusa and
mushroom. |
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Diseases |
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Disease Link |
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