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DiaMedBase ID |
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DMPAe027 |
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Medicinal Plant
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Ajuga iva |
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Plant part(s)
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Whole plant |
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Objective |
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To investigate the hypoglycaemic effect
of the lyophilised aqueous extract of the whole plant of Ajuga iva in
normal and streptozotocin-induced diabetic rats |
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Journal Source
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J Ethnopharmacol.
2002; 80(2-3):109-113 |
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Title
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Hypoglycaemic effect of the
lyophilised aqueous extract of Ajuga iva in normal and streptozotocin
diabetic rats |
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Authors
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Hilaly JE, Lyoussi B. |
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Address
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Faculty of Sciences Dhar El Mehraz, UFR
Physiology - Pharmacology, Laboratory of Animal Physiology, Department
of Biology, USMBA, BP 1976, Atlas, Fez, Morocco |
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Abstract
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The purpose of this study was to
examine the hypoglycaemic effect of the lyophilised aqueous extract of
the whole plant of Ajuga iva (L.) Schreber (Labiatae) in normal and
streptozotocin-induced diabetic rats. Single and repeated oral
administration of the extract of Ajuga iva L (AI) at a dose of 10
mg/kg produced a slight and significant decrease in plasma glucose
levels in normal rats 6 h after administration and after 3 weeks of
treatment. AI reduced plasma glucose levels of streptozotocin diabetic
rats from 337+/-9.3 to 102.2+/-17.7 mg/dl after 6 h of oral
administration (P<0.001). Repeated oral administration of AI to
streptozotocin diabetic rats significantly decreased the plasma
glucose levels after 1 week of treatment (112+/-14.4 mg/dl at 1 week
vs 337+/-9.3 mg/dl at the baseline values, (P<0.001). It continuously
decreased thereafter and showed a rapid normalisation after 1 week of
AI treatment. It is concluded that these results demonstrated that the
water extract of the whole plant of AI possess a strong hypoglycaemic
effect in diabetic rats, and support therefore, its traditional use in
diabetes mellitus control. |
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Diseases |
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Disease Link |
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