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DiaMedBase ID |
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DMPAo054 |
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Medicinal Plant
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Anacardium occidentale |
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Plant part(s)
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Whole plant |
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Objective |
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To study the
effect of Anacardium occidentale aqueous extract against
streptozotocin-induced diabetes in rats |
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Journal Source
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J
Ethnopharmacol.
1998; 62(2):95-99 |
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Title
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Protective role of Anacardium occidentale extract against
streptozotocin-induced diabetes in rats |
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Authors
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Kamtchouing P,
Sokeng SD, Moundipa PF, Watcho P, Jatsa HB, Lontsi D |
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Address
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Department of
Animal Biology and Physiology, Faculty of Science, University of
Yaounde 1, Cameroon |
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Abstract
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The protective
effect of Anacardium occidentale aqueous extract against
streptozotocin-induced diabetes was evaluated in rats. The rats were
treated with 175 mg/kg of the extract per os, twice daily; beginning 2
days before streptozotocin (STZ) injection. A total of 3 days after
STZ administration, there was a 48% increase in blood glucose level in
pretreated rats, compared with a 208% increase in diabetic control
rats treated with STZ alone. Furthermore, these pretreated animals
presented no glycosuria, a normal weight gain and a non significant
increase in food and fluid intake at the end of the treatment compared
with the normal control. Diabetic control animals showed a positive
glycosuria, body weight loss, a real polyphagia and polydypsia. These
results indicate the protective role of Anacardium occidentale extract
against the diabetogenic action of STZ. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPAo055 |
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Medicinal Plant
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Burdock
(Arctium lappa), cashew (Anacardium occidentale), dandelion (Taraxacum
officinale), elder (Sambucus nigra), fenugreek (Trigonella
foenum-graecum), guayusa (Ilex guayusa), hop (Humulus lupulus), nettle
(Urtica dioica), cultivated mushroom (Agaricus bisporus), periwinkle (Catharanthus
roseus), sage (Salvia officinale), and wild carrot (Daucus carrota) |
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Plant part(s)
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Whole plant |
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Objective |
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To study the
glycemic effect |
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Journal Source
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Diabetes Res.,
1989; 10(2):69-73 |
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Title
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Glycaemic
effects of traditional European plant treatments for diabetes. Studies
in normal and streptozotocin diabetic mice |
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Authors
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Swanston-Flatt SK,
Day C, Flatt PR, Gould BJ, Bailey CJ |
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Address
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Department of
Biochemistry, University of Surrey, Guildford, UK |
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Abstract
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Twelve plants used for the traditional
treatmessnt of diabetes mellitus in northern Europe were studied using
normal and streptozotocin diabetic mice to evaluate effects on glucose
homeostasis. The plants were administered in the diet (6.25% by
weight) and/or as decoctions or infusions in place of drinking water,
to coincide with the traditional method of preparation. Treatment for
28 days with preparations of burdock (Arctium lappa), cashew
(Anacardium occidentale), dandelion (Taraxacum officinale), elder (Sambucus
nigra), fenugreek (Trigonella foenum-graecum), guayusa (Ilex guayusa),
hop (Humulus lupulus), nettle (Urtica dioica), cultivated mushroom
(Agaricus bisporus), periwinkle (Catharanthus roseus), sage (Salvia
officinale), and wild carrot (Daucus carrota) did not affect the
parameters of glucose homeostasis examined in normal mice (basal
plasma glucose and insulin, glucose tolerance, insulin-induced
hypoglycaemia and glycated haemoglobin). After administration of
streptozotocin (200 mg/kg) burdock and nettle aggravated the diabetic
condition, while cashew, dandelion, elder, fenugreek, hop, periwinkle,
sage and wild carrot did not significantly affect the parameters of
glucose homeostasis studied (basal glucose and insulin,
insulin-induced hypoglycaemia, glycated haemoglobin and pancreatic
insulin concentration). Guayusa and mushroom retarded the development
of hyperglycaemia in streptozotocin diabetes and reduced the
hyperphagia, polydipsia, body weight loss, and glycated haemoglobin.
Mushroom also countered the initial reduction in plasma insulin and
the reduction in pancreatic insulin concentration, and improved the
hypoglycaemic effect of exogenous insulin. These studies suggest the
presence of potentially useful antidiabetic agents in guayusa and
mushroom. |
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Diseases |
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Disease Link |
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