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DiaMedBase ID |
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DMPAs062 |
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Medicinal Plant
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Annona squamosa |
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Plant part(s)
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Leaves |
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Objective |
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To study the leaf alcohol
extract of the plant Annona squamosa for its antidiabetic
activity |
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Journal Source
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Pharmaceutical Biology
(Formerly International Journal of Pharmacognosy),
2004; 42(1):30-35 |
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Title
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Oral Antidiabetic
Activity of Annona squamosa Leaf Alcohol Extract in NIDDM Rats |
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Authors
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Annie Shirwaikar A1,
K. Rajendran A1, Dinesh C. Kumar A1 |
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Address
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A1 Department
of Pharmacognosy College of Pharmaceutical Sciences Manipal India |
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Abstract
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The leaf alcohol extract
of the plant Annona squamosa was investigated for its
antidiabetic activity. Type 2 diabetes mellitus was induced with
standardised doses of streptozotocin and nicotinamide. Graded doses of
the leaf alcohol extract suspended in gum acacia were administered to
normal and experimental diabetic rats for 12 days. Fasting plasma
glucose levels, serum insulin levels, serum lipid profiles and changes
in body weight were evaluated in normal rats while liver glycogen
levels and pancreatic TBARS levels were evaluated additionally in
diabetic rats. The diabetic groups treated with the leaf alcohol
extract were compared with standard glibenclamide. The findings showed
the significant antidiabetic potential of the extract in ameliorating
the diabetic conditions in diabetic rats. No significant effects were
found in the normal rats. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
|
DMPAs063 |
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Medicinal Plant
|
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Annona squamosa |
|
Plant part(s)
|
|
Leaves |
|
Objective |
|
To investigate the
antidiabetic properties of the young leaves of Annona squamosa |
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Journal Source
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J Ethnopharmacol.
2004; 91(1):171-175 |
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Title
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Antidiabetic activity
of aqueous leaf extract of Annona squamosa in
streptozotocin-nicotinamide type 2 diabetic rats |
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Authors
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Shirwaikar A, Rajendran K,
Dinesh Kumar C, Bodla R |
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Address
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Department of
Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119,
India. annieshirwaikar@yahoo.com |
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Abstract
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The claim by some tribal
populations in parts of Northern India that the young leaves of the
custard apple tree, Annona squamosa L. (Annonaceae) has antidiabetic
properties was investigated. Diabetes mellitus was induced with
streptozotocin-nicotinamide and graded doses of the aqueous leaf
extracts were then administered in drinking water to normal and
experimental diabetic rats for 12 days. Fasting plasma glucose levels,
serum insulin levels, serum lipid profiles and changes in body weight
were evaluated in normal rats while liver glycogen levels and
pancreatic TBARS levels were evaluated additionally in diabetic rats.
The diabetic groups treated with the aqueous leaf extract were
compared with standard glibenclamide. The findings of the study
support the antidiabetic claims of Annona squamosa. |
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Diseases |
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Disease Link |
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