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DiaMedBase ID |
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DMPAv064 |
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Medicinal Plant
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Apocynum venetum L. |
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Plant part(s)
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Leaves |
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Objective |
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To study the activity of Luobuma leaf extract and its
components against the formation of advanced glycation endproducts (AGEs) |
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Journal Source
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Food and Chemical Toxicology
2004;42:975-981 |
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Title
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Inhibitory effects of Luobuma tea and its
components against glucose-mediated protein damage |
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Authors
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Takako Yokozawa, Takako Nakagawa |
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Address
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Institute of Natural Medicine, Toyama Medical and
Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan |
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Abstract
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Luobuma tea, prepared from
the leaves of Apocynum venetum L., is a popular beverage in China. In
this study, the activity of Luobuma leaf extract and its components
against the formation of advanced glycation endproducts (AGEs), which
are largely involved in the pathogenesis of diabetic vascular
complications, was examined using the in vitro glycation reaction.
Strong inhibitory activity against the formation of AGEs was shown by
Luobuma aqueous extract. Following further fractionation of this
extract, seven polyphenolic compounds, i.e. ( )-gallocatechin, ( )-epigallocatechin,
( )-catechin, ( )-epicatechin, epicatechin-(4b-8)- gallocatechin,
epigallocatechin-(4b-8)-epicatechin and procyanidin B-2, were isolated
by Sephadex LH-20 column chromatography. These purified compounds also
exerted inhibitory activities that were more potent than the positive
control, aminoguanidine. Our findings may help to explain the beneficial
effects of this plant against atherosclerosis. |
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Diseases |
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Disease Link |
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