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DiaMedBase ID |
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DMPAd065 |
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Medicinal Plant
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Aralia dasyphylla
Miq |
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Plant part(s)
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Triterpenoids and glycosides from whole
plant |
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Objective |
|
To investigate the hypoglycemic effect
of triterpenoids and glycosides from
Aralia dasyphylla Miq |
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Journal Source
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Yao
Xue Xue Bao,
1997; 32(10):769-72 |
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Title
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Studies on triterpenoids and their
glycosides from Aralia dasyphylla Miq |
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Authors
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Yi YH, Gu JQ, Xiao K, Wang ZZ, Lin HW |
|
Address
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Department of Medical Chemistry of
Natural Products, School of Pharmacy, Second Military Medical
University, Shanghai 200433 |
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Abstract
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The structures of two triterpenoids and
their glycosides were isolated from Aralia dasyphylla Miq. Their
structures have been identified to be oleanoic acid(I), 16
beta-hydroxy-18 beta-H-oleanoic acid(II), oleanoic
acid-28-O-beta-D-glucopyranoside(III) and 16 beta-hydroxy-18 beta-H-oleanoic
acid-28-O-beta-D-glucopyranoside(IV), respectively, mainly through
interpretation of UV, IR, MS, 1H and 13CNMR, DEPT, HMQC and HMBC
spectra data. The stereochemistry of II has been confirmed by NOESY.
Pharmacological experiments showed that the total saponins exerted
preventative effect on CCl4-induced liver injury of male mice and
hypoglycemic effect on a model of alloxan-induced diabetes in rats. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPAc066 |
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Medicinal Plant
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Phellodendron cortex and Aralia cortex |
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Plant part(s)
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Cortex |
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Objective |
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To
study the activity of the water extract of Phellodendron cortex and
Aralia cortex |
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Journal Source
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Phytother
Res.
1999; 13(7):555-560 |
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Title
|
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Effects of water extract of 1:1 mixture
of Phellodendron cortex and Aralia cortex on polyol pathway and
oxidative damage in lenses of diabetic rats |
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Authors
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Lee
Y, Kim H, Choi HS, Kang BH, Han YB, Kim SJ |
|
Address
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Department of Food and Nutrition,
College of Human Ecology, Seoul National University,Seoul 151-742,
Korea |
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Abstract
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Enhanced activity of the polyol pathway
and oxidative damage have been implicated in the pathogenesis of
diabetic cataract. We decided to investigate whether these changes in
diabetic lenses could be prevented by the water extract of
Phellodendron cortex and Aralia cortex (P55A). Aldose reductase
activity was inhibited significantly by the treatment with P55A.
Consequently, it caused a dramatic reduction in the high sorbitol
contents observed in the lenses of diabetic rats. In addition, the
greatly elevated content of thiobarbituric acid reactive substances (TBARS)
and carbonylated protein in diabetic rats were reduced by P55A
treatment. These results suggest that P55A extract exerts an
antioxidant effect by reducing lipid peroxidation and protein
carbonylation as well as having an inhibitory action against aldose
reductase in the lenses of diabetic rats. |
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Diseases |
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Disease Link |
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