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DiaMedBase ID |
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DMPAl067 |
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Medicinal Plant
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Burdock (Arctium lappa), cashew (Anacardium occidentale),
dandelion (Taraxacum officinale), elder (Sambucus nigra), fenugreek (Trigonella
foenum-graecum), guayusa (Ilex guayusa), hop (Humulus lupulus), nettle
(Urtica dioica), cultivated mushroom (Agaricus bisporus), periwinkle
(Catharanthus roseus), sage (Salvia officinale), and wild carrot
(Daucus carrota) |
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Plant part(s)
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Whole
plant |
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Objective |
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To
study the glycemic effect |
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Journal Source
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Diabetes Res.,
1989; 10(2):69-73 |
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Title
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Glycaemic effects of traditional European plant treatments for
diabetes. Studies in normal and streptozotocin diabetic mice |
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Authors
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Swanston-Flatt SK, Day C, Flatt PR, Gould BJ, Bailey CJ |
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Address
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Department of Biochemistry, University of Surrey, Guildford, UK |
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Abstract
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Twelve plants used for the
traditional treatment of diabetes mellitus in northern Europe were
studied using normal and streptozotocin diabetic mice to evaluate
effects on glucose homeostasis. The plants were administered in the
diet (6.25% by weight) and/or as decoctions or infusions in place of
drinking water, to coincide with the traditional method of
preparation. Treatment for 28 days with preparations of burdock
(Arctium lappa), cashew (Anacardium occidentale), dandelion (Taraxacum
officinale), elder (Sambucus nigra), fenugreek (Trigonella
foenum-graecum), guayusa (Ilex guayusa), hop (Humulus lupulus), nettle
(Urtica dioica), cultivated mushroom (Agaricus bisporus), periwinkle
(Catharanthus roseus), sage (Salvia officinale), and wild carrot
(Daucus carrota) did not affect the parameters of glucose homeostasis
examined in normal mice (basal plasma glucose and insulin, glucose
tolerance, insulin-induced hypoglycaemia and glycated haemoglobin).
After administration of streptozotocin (200 mg/kg) burdock and nettle
aggravated the diabetic condition, while cashew, dandelion, elder,
fenugreek, hop, periwinkle, sage and wild carrot did not significantly
affect the parameters of glucose homeostasis studied (basal glucose
and insulin, insulin-induced hypoglycaemia, glycated haemoglobin and
pancreatic insulin concentration). Guayusa and mushroom retarded the
development of hyperglycaemia in streptozotocin diabetes and reduced
the hyperphagia, polydipsia, body weight loss, and glycated
haemoglobin. Mushroom also countered the initial reduction in plasma
insulin and the reduction in pancreatic insulin concentration, and
improved the hypoglycaemic effect of exogenous insulin. These studies
suggest the presence of potentially useful antidiabetic agents in
guayusa and mushroom. |
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Diseases |
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Disease Link |
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