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DiaMedBase ID |
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DMPAc094 |
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Medicinal Plant
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Azorella compacta |
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Plant part(s)
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Whole plant |
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Objective |
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To determine the
diterpenic compounds isolated from Azorella compacta are
responsible for antihyperglycemic effect in streptozotocin diabetic
rats |
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Journal Source
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Phytotherapy Research,
2005; 19(8):713-716 |
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Title
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Experimental
antihyperglycemic effect of diterpenoids of llareta Azorella
compacta (Umbelliferae) Phil in rats
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Authors
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Nelson L. Fuentes
1, Hernan Sagua
2, Glauco Morales
3, Jorge Borquez
3, Aurelio San Martin
4, Julia Soto
5, Luis A Loyola
3 |
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Address
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1Biomedical
Department, University of Antofagasta, Antofagasta, Chile
2Unit of Parasitology,
Faculty of Health Sciences, University of Antofagasta, Antofagasta,
Chile 3Laboratory
of Natural Products Department of Chemistry, Faculty of Basic
Sciences, University of Antofagasta, Antofagasta, Chile
4Department of Chemistry,
Faculty of Sciences, University of Chile, Santiago, Chile
5Unit of Molecular Biology
and Development, Clinical Laboratory Services, Faculty of Medicine,
Catholic University of Chile, Santiago, Chile |
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Abstract
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Aqueous or ethanol
infusions of Azorella compacta (llareta) in common with many
other plants have been used as antidiabetic in the popular medicine in
the altiplanic region of Chile. In order to determine if the
diterpenic compounds chemically elucidated and isolated from this
plant are responsible for this effect, streptozotocin diabetic rats
(507 ± 67 mg/mL glucose) were injected with two injections of
diterpenic compounds mulinolic acid, azorellanol, and
mulin-11,13-dien-20-oic acid at 180 mg/mL. Glycemia of animals treated
with mulinolic acid and azorellanol was decreased to 243 ± 2 and 247 ±
14 mg/mL respectively, values very close to those reached by
chlorpropamide injection used in controls. After 3 h treatment with
mulin-11,13-dien-20-oic acid no effect was detected. The blood serum
insulin in diabetic rats (146 ± 58 pg/mL) was lower than in control
rats. After injection of azorellanol, insulin was elevated to 247 ± 23
pg/mL but with mulinolic acid, insulin was not changed. The
antihyperglycemic effect of these compounds may explain the
effectiveness of llareta in popular medicine. Because of the
similarity to the hypoglycemic medication chlorpropamide, azorellanol
could be acting on the cells of pancreatic islets, while mulinolic
acid may act upon glucose utilization or production in the liver. |
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Diseases |
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Disease Link |
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