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DiaMedBase ID
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DMPLs366 |
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Medicinal Plant
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Lagerstroemia speciosa |
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Plant part(s)
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Leaves |
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Objective
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To study the Glucose
transport enhancers in Lagerstroemia speciosa used for diabetes
mellitus |
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Journal Source
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Planta Med.
2002; 68(2):173-175 |
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Title
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Ellagitannins from
Lagerstroemia speciosa as activators of glucose transport in fat cells |
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Authors
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Hayashi T, Maruyama H,
Kasai R, Hattori K, Takasuga S, Hazeki O, Yamasaki K, Tanaka T |
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Address
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Not available |
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Abstract
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Glucose transport
enhancers were searched for in Lagerstroemia speciosa, a Philippine
local herbal medicine used for diabetes mellitus. Bioassay-guided
fractionation of the aqueous acetone extract of the leaves afforded
three active ellagitannins, lagerstroemin, flosin B and reginin A,
identified by NMR and optical rotation. These compounds increased
glucose uptake of rat adipocytes, and could be responsible for
lowering the blood glucose level. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPLs367 |
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Medicinal Plant
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Lagerstroemia speciosa L. |
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Plant part(s)
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Leaves |
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Objective |
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To
study the hypoglycemic effects of Lagerstroemia speciosa L. using
hereditary diabetic mice. |
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Journal Source
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Biosci
Biotechnol Biochem.
1996; 60(2):204-208 |
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Title
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Hypoglycemic effect of extracts from
Lagerstroemia speciosa L. leaves in genetically diabetic KK-AY mice |
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Authors
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Kakuda T, Sakane I, Takihara T, Ozaki Y, Takeuchi H, Kuroyanagi M |
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Address
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Central Research Institute, Itoen, Ltd.,
Sagara-cho, Haibara-gun, Shizuoka, Japan |
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Abstract
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The
hypoglycemic effects of Lagerstroemia speciosa L., known by the
Tagalog name of banaba in the Phillipines, were studied using
hereditary diabetic mice (Type II, KK-AY/Ta Jcl). The mice were fed a
test diet containing 5% of the hot-water extract (HWE) from banaba
leaves, 3% of the water eluent of the partial fraction unadsorbed onto
HP-20 resin of HWE (HPWE), and 2% of the methanol eluent of the
partial fraction adsorbed onto HP-20 resin of it (HPME) for a feeding
period of 5 weeks. The elevation of blood plasma glucose level in
non-insulin dependent diabetic mice fed the cellulose as control (CEL)
diet were almost entirely suppressed by addition of either HWE or HPME
in place of cellulose in the CEL diet. Water intakes were inclined to
increase gradually in the group fed either CEL or HPWE, but lower in
the mice fed either HWE or HPME than in the animals given either CEL
or HPME. The level of serum insulin and the amount of urinary excreted
glucose were also lowered in mice fed HWE. Plasma total cholesterol
level was also lowered in mice fed the either HWE or HPME. It is
suggested that HWE, especially HPME, obtained from banaba leaves have
beneficial effects on control of the level of plasma glucose in
non-insulin dependent diabetes mellitus. |
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Diseases |
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Disease Link |
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