|
|
|
|
DiaMedBase ID |
|
DMPLc373 |
|
Medicinal Plant
|
|
Lepechinia caulescens |
|
Plant part(s)
|
|
Flowers |
|
Objective |
|
To study the blood glucose
level decrease caused by extracts and fractions from Lepechinia
caulescens |
|
Journal Source
|
|
Pharmaceutical Biology
(Formerly International Journal of Pharmacognosy),
2001; 39(4):317-321 |
|
Title
|
|
Blood Glucose Level
Decrease Caused by Extracts and Fractions from Lepechinia caulescens
in Healthy and Alloxan-diabetic Mice |
|
Authors
|
|
R. Roman-Ramos, C.C.
Contreras-Weber, G. Nohpal-Grajeda, J.L. Flores-Saenz, F.J. Alarcon-Aguilar |
|
Address
|
|
Not available |
|
Abstract
|
|
The traditional
preparation, hexane, methylene chloride, methanol and water extracts
obtained from the flowers of Lepechinia caulescens (Labiatae) were
administered to fasting healthy mice. The investigation results showed
that only the traditional preparation and the water extract
significantly reduce blood glucose after intraperitoneal
administration (P < 0.05). The water extract, whose effects were in a
dose-dependent manner, was macerated with methanol obtaining a
precipitate (F1 fraction) and a methanol soluble fraction (F2
fraction), and both were studied in healthy mice. Methanol fraction F2
did not significantly decrease blood glucose level in this
experimental model. The water fraction F1 showed significant
hypoglycemic activity in healthy and mild alloxan-diabetic mice, but
not in severe alloxan-diabetic mice. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPLc374 |
|
Medicinal Plant
|
|
Cucurbita ficifolia,
Guaiacum coulteri, Lepechinia caulescens, and Psacalium
peltatum |
|
Plant part(s)
|
|
Whole
plant |
|
Objective |
|
to
study the Hypoglycemic activity of some antidiabetic plants |
|
Journal Source
|
|
Arch Med Res.
1992; 23(3):105-109 |
|
Title
|
|
Hypoglycemic activity
of some antidiabetic plants |
|
Authors
|
|
Roman
Ramos R, Lara Lemus A, Alarcon Aguilar F, Flores Saenz JL |
|
Address
|
|
Health Science Department, Biological and Health Sciences Division,
Metropolitan Autonomous University, Iztapalapa Campus, Mexico, D.F |
|
Abstract
|
|
To
assess the hypoglycemic activity mechanism of some plants used
empirically by the Mexican population as antidiabetics, traditional
preparations of Cucurbita ficifolia, Guaiacum coulteri, Lepechinia
caulescens, and Psacalium peltatum, water, tolbutamide, and Regular
Insulin were administered to three groups of rabbits each: 1. Healthy
rabbits with temporary hyperglycemia induced by the subcutaneous
administration of glucose. 2. Rabbits with moderate diabetes (fasting
glycemia 150-300 mg/dl), induced with alloxan. 3. Rabbits with severe
diabetes (fasting glycemia higher than 400 mg/dl), induced with
alloxan. The plant preparations had a hypoglycemic effect similar to
tolbutamide in healthy and mild diabetic rabbits and had no effect in
severely diabetic rabbits. These results suggest that some pancreatic
function or the presence of insulin is required for the hypoglycemic
activity of these plants. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPLc375 |
|
Medicinal Plant
|
|
Guazuma ulmifolia,
Tournefortia hirsutissima, Lepechinia caulescens, Rhizophora
mangle, Musa sapientum, Trigonella foenum graceum, Turnera diffusa,
and Euphorbia prostrata |
|
Plant part(s)
|
|
Whole
plant |
|
Objective |
|
To study the
hypoglycemic effect of 28
medicinal plants used in the treatment of diabetes mellitus |
|
Journal Source
|
|
J Ethnopharmacol.
1998; 61(2):101-110 |
|
Title
|
|
Study of the
anti-hyperglycemic effect of plants used as antidiabetics |
|
Authors
|
|
Alarcon-Aguilara FJ, Roman-Ramos R,
Perez-Gutierrez S, Aguilar-Contreras A, Contreras-Weber CC,
Flores-Saenz JL |
|
Address
|
|
Departamento de Ciencias de la Salud,
Universidad Autonoma Metropolitana Iztapalapa, Mexico, DF, Mexico |
|
Abstract
|
|
The purpose of this research was to
study the anti-hyperglycemic effect of 28 medicinal plants used in the
treatment of diabetes mellitus. Each plant was processed in the
traditional way and intragastrically administered to temporarily
hyperglycemic rabbits. The results showed that eight out of the 28
studied plants significantly decrease the hyperglycemic peak and/or
the area under the glucose tolerance curve. These plants were: Guazuma
ulmifolia, Tournefortia hirsutissima, Lepechinia caulescens,
Rhizophora mangle, Musa sapientum, Trigonella foenum graceum, Turnera
diffusa, and Euphorbia prostrata. The results suggest the validity of
their clinical use in diabetes mellitus control, after their
toxicological investigation. |
|
Diseases |
|
Disease Link |
|
