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DiaMedBase ID |
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DMPLs376 |
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Medicinal Plant
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Lepidium sativum |
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Plant part(s)
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Seeds |
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Objective |
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To investigate the
hypoglycaemic effect of an aqueous extract of Lepidium sativum L. (LS)
seeds in normal and streptozotocin (STZ)-induced diabetic rats |
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Journal Source
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J Ethnopharmacol.
2005; 97(2):391-395 |
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Title
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Study of the
hypoglycaemic activity of Lepidium sativum L. aqueous extract in
normal and diabetic rats |
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Authors
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Eddouks M, Maghrani M,
Zeggwagh NA, Michel JB |
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Address
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UFR PNPE P.B. 21,
Errachidia 52000, Morocco. m.eddouks@caramail.com |
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Abstract
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The hypoglycaemic effect
of an aqueous extract of Lepidium sativum L. (LS) seeds was
investigated in normal and streptozotocin (STZ)-induced diabetic rats.
After a acute (single dose) or chronic (15 daily repeated
administration) oral treatments, the aqueous LS extract (20 mg/kg)
produced a significant decrease on blood glucose levels in STZ
diabetic rats (p < 0.001); the blood glucose levels were normalised 2
weeks after daily repeated oral administration of aqueous LS extract
(20 mg/kg) (p < 0.001). Significant reduction on blood glucose levels
were noticed in normal rats after both acute (p < 0.01) and chronic
treatment (p < 0.001). In addition, no changes were observed in basal
plasma insulin concentrations after treatment either in normal or STZ
diabetic rats indicating that the underlying mechanism of this
pharmacological activity seems to be independent of insulin secretion.
We conclude that the aqueous extract of LS exhibits a potent
hypoglycaemic activity in rats without affecting basal plasma insulin
concentrations. |
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Diseases |
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Disease Link |
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