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DiaMedBase ID
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DMPAa003 |
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Medicinal Plant
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Azadirachta indica
and Abroma augusta |
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Plant part(s)
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Roots and Leaves |
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Objective
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To investigate the effect
of bolood sugar when administered orally to alloxan diabetic rats |
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Journal Source
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Indian J Exp
Biol. 2003; 41(6):636-640 |
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Title
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Lowering of blood sugar
by water extract of Azadirachta indica and Abroma augusta in diabetes
rats |
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Authors
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Halim EM |
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Address
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National Chemical
Laboratory, Pune 411008, India. prs@ems.ncl.res.in |
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Abstract
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Combination (1:1 ) of
water extract of dried powder of root and leaves (200 mg/kg body wt)
of A. augusta and A. indica respectively was administered orally to
alloxan diabetic rats once a day for 8 weeks. This treatment caused
significant lowering of blood sugar in fasted as estimated by glucose
tolerance test. The treatment resulted in a significant reduction in
serum lipids. Aqueous extract also decreased the formation of lipid
peroxides estimated as thiobarbituric acid reactive substance, (TBARS),
and increased antioxidants
(superoxide dismutase, catalase, glutathione peroxidase and
glutathione transferase) in erythrocytes. There was reduction in LPO
as TBARS in heart, liver, kidney, and muscles. It also prevented
decrease in body weight. Present study showed that Abroma augusta
roots and A. indica leaves when given together as water extract had
hypoglycaemic action and had better effect than given alone. |
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Diseases |
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Disease Link |
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