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|
|
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DiaMedBase ID |
|
DMPPo499 |
|
Medicinal Plant
|
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Pandanus odorus
|
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Plant part(s)
|
|
Roots |
|
Objective |
|
To study the
hypoglycemic effect of extract of the root of Pandanus odorus |
|
Journal Source
|
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Biol Pharm Bull;
1996; 19(3):364-366 |
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Title
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Hypoglycemic
effect of water extract of the root of Pandanus odorus RIDL |
|
Authors
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Peungvicha P,
Thirawarapan SS, Watanabe H |
|
Address
|
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Department of Physiology, Faculty of
Pharmacy, Mahidol University, Bangkok,Thailand |
|
Abstract
|
|
Hypoglycemic
effect of water extract of the root of Pandanus odorus RIDL. (Thai
name: Toei-hom, Pandanaceae) was examined in normal and streptozotocin-diabetic
rats. In the hypoglycemic test without glucose load, an administration
of the extract at doses of 0.125-0.5g/kg p.o. did not affect
significantly the plasma glucose level in normal rats, whereas the
extract significantly lowered the plasma glucose level at a dose of
0.5g/kg p.o. in diabetic rats. In oral glucose tolerance test, an
administration of the extract at a dose of 0.5g/kg p.o. significantly
lowered the plasma glucose level in normal rats. The extract at doses
of 0.5 and 1.0g/kg p.o. also significantly lowered the plasma glucose
level in diabetic rats. A reference drug, glibenclamide at a dose of 5
mg/kg p.o. showed a significant hypoglycemic effect in both normal and
diabetic rats. Repeated administration of the extract at doses of 0.25
and 0.5 g/kg p.o. for 7d produced a significant hypoglycemic effect in
diabetic rats. Glibenclamide (5 mg/kg p.o.) also caused a significant
hypoglycemia in the diabetic rats. LD50 (95% confidence limit) after
intraperitoneal injection was 1.87 (1.26-2.76)g/kg in male and female
rats and 1.62 (1.18-2.24)g/kg in male and female mice, respectively.
The LD50 after oral administration was over 8 g/kg in both sexes of
rat and mice. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPPo500 |
|
Medicinal Plant
|
|
Pandanus odorus |
|
Plant part(s)
|
|
Roots |
|
Objective |
|
To study the
hypoglycemic effect of extract of the root of Pandanus odorus |
|
Journal Source
|
|
J Ethnopharmacol.
1998; 62(1):79-84 |
|
Title
|
|
4-Hydroxybenzoic acid: a
hypoglycemic constituent of aqueous extract of Pandanus odorus root |
|
Authors
|
|
Peungvicha P, Temsiririrkkul R, Prasain
JK, Tezuka Y, Kadota S, Thirawarapan SS, Watanabe H |
|
Address
|
|
Faculty of Pharmacy, Mahidol
University, Bangkok, Thailand. pyppv@mahidol.ac.th |
|
Abstract
|
|
Hypoglycemic activity-guided fraction
led to the isolation of the known compound, 4-hydroxybenzoic acid,
from Pandanus odorus Ridl. (Thai name: Toei-hom, Pandanaceae). This
compound showed a hypoglycemic effect in normal rats after the oral
administration of 5 mg/kg. Additionally, the compound increased serum
insulin levels and liver glycogen content in normal rats. |
|
Diseases |
|
Disease Link |
|
DiaMedBase ID |
|
DMPPo501 |
|
Medicinal Plant
|
|
Pandanus odorus |
|
Plant part(s)
|
|
Roots |
|
Objective |
|
To study the
hypoglycemic effect of the root of Pandanus odorus Ridl
|
|
Journal Source
|
|
Jpn J Pharmacol.
1998; 78(3):395-398 |
|
Title
|
|
Possible mechanism of hypoglycemic
effect of 4-hydroxybenzoic acid, a constituent of Pandanus odorus
root. |
|
Authors
|
|
Peungvicha P,
Thirawarapan SS, Watanabe H |
|
Address
|
|
Department of Physiology, Faculty of
Pharmacy, Mahidol University, Bangkok, Thailand |
|
Abstract
|
|
We studied the hypoglycemic effect of
4-hydroxybenzoic acid, a constituent of the root of Pandanus odorus
Ridl. (Pandanaceae, Thai name: Toei-hom), in streptozotocin-diabetic
rats. Oral administration of 4-hydroxybenzoic acid caused a decrease
in plasma glucose levels dose-dependently in the diabetic rat. The
constituent did not affect serum insulin level and liver glycogen
content in the diabetic model, but increased glucose consumption in
normal and diabetic rat diaphragms. These results suggest that
4-hydroxybenzoic acid produces a hypoglycemic effect mediated by an
increase in the peripheral glucose consumption. |
|
Diseases |
|
Disease Link |
|
