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DiaMedBase ID |
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DMPPa502 |
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Medicinal Plant
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Pantoea agglomerans |
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Plant part(s)
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Whole plant |
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Objective |
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To study the
ability of a lipopolysaccharide in suppression of hyperalgesia |
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Journal Source
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Biol Pharm Bull.
1994; 17(5):632-634 |
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Title
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Suppression of hyperalgesia in
streptozotocin-induced diabetic mice by a lipopolysaccharide from
Pantoea agglomerans |
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Authors
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Kamei J, Iwamoto
Y, Suzuki T, Misawa M, Kasuya Y, Okutomi T, Soma G, Mizuno D |
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Address
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Department of Pharmacology, Faculty of
Pharmaceutical Sciences, Hoshi University, Tokyo, Japan |
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Abstract
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The ability of a lipopolysaccharide from
Pantoea agglomerans (LPSp) to relieve hyperalgesia was examined by
observing its inhibition of the decrease in the threshold for
nociceptive perception, as determined by the tail-pinch test, in
streptozotocin-induced diabetic mice. Subcutaneous injection of LPSp
suppressed hyperalgesia in streptozotocin-induced diabetic mice and
also exerted a therapeutic effect on hyperalgesia in these animals.
The present data suggest that LPSp may be effective in relieving the
pain associated with diabetic neuropathy. |
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Diseases |
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Disease Link |
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