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DiaMedBase ID
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DMPPa526 |
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Medicinal Plant
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Phytolacca americana |
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Plant part(s)
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Roots |
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Objective
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To investigate the inhibitory
activity-guided fractionation for the high glucose-induced
proliferation of glomerular mesangial cells (GMCs) |
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Journal Source
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Planta Med.
2004; 70(8):736-739 |
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Title
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alpha-Spinasterol isolated from the
root of Phytolacca americana and its pharmacological property on
diabetic nephropathy |
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Authors
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Jeong SI, Kim KJ, Choi MK, Keum KS, Lee
S, Ahn SH, Back SH, Song JH, Ju YS, Choi BK, Jung KY |
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Address
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Department of Pharmacology, Wonkwang
University School of Medicine, Jeonbuk, Korea |
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Abstract
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Based on an inhibitory activity-guided
fractionation for the high glucose-induced proliferation of glomerular
mesangial cells (GMCs), chloroform extracts of the roots of Phytolacca
americana were found to contain alpha-spinasterol (C (29)H (48)O), a
delta (7)-sterol. This phytosterol proved to be a potent inhibitor (IC
(50) = 3.9 x 10 (-12) g/mL, 9.5 pmol/L) of glomerular mesangial cell
proliferation caused by high-ambient glucose (5.6 mM vs. 25 mM), and
its inhibitory potency was about 1,000 times higher than that of
simvastatin, an HMG-CoA reductase inhibitor used as a positive
control. alpha-Spinasterol also significantly reduced the increases of
serum triglycerides, renal weight and urinary protein excretion in
streptozotocin-induced diabetic mice, and these were comparable to the
results observed in insulin-treated diabetic mice. Therefore, the
results obtained in this study suggest that alpha-spinasterol has a
significant therapeutic potential to modulate the development and/or
progression of diabetic nephropathy. |
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Diseases |
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Disease Link |
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