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DiaMedBase ID
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DMPPs532 |
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Medicinal Plant
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Polygala senega |
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Plant part(s)
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Rhizome |
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Objective
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To study the hypoglycemic effect in
normal and KK-Ay mice |
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Journal Source
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Planta Med. 1996;
62(5):440-443 |
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Title
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Hypoglycemic effect of the rhizomes
of Polygala senega in normal and diabetic mice and its main component,
the triterpenoid glycoside senegin-II |
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Authors
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Kako M, Miura T, Nishiyama Y, Ichimaru
M, Moriyasu M, Kato A |
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Address
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Suzuka University of Medical Science
and Technology, Mie, Japan |
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Abstract
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The hypoglycemic effect of the rhizomes
of Polygala senega L. var. latifolia Torrey et Gray (Polygalaceae) was
investigated in normal and KK-Ay mice, one of the model animals of
non-insulin dependent diabetes mellitus (NIDDM). The n-butanol extract
of senega rhizomes (SN) (5 mg/kg) reduced the blood glucose of normal
mice from 191 +/- 3 to 120 +/- 3 mg/dl 4 hours after intraperitoneal
administration (P < 0.001), and also showed a significant decrease in
the glucose level of KK-Ay mice from 469 +/- 38 to 244 +/- 14 mg/dl
under similar conditions (P < 0.001). But streptozotocin-induced
diabetic mice did not experience a change in the blood glucose after
administration of SN. We propose that the hypoglycemic effect of SN
occurs without altering the insulin concentration. Moreover, SN needs
the presence of insulin in order to act. In addition, one of the
active components of the hypoglycemic effect was identified as a
triterpenoid glycoside, senegin-II. |
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Diseases |
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Disease Link |
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