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DiaMedBase ID
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DMPPo533 |
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Medicinal Plant
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Polygonatum officinale |
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Plant part(s)
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Rhizomes
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Objective
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To study the hypoglycemic effect in
normal and streptozotocin-induced diabetic mice |
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Journal Source
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Planta Med.
1994; 60(3):201-3 |
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Title
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Hypoglycemic action of the rhizomes
of Polygonatum officinale in normal and diabetic mice |
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Authors
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Kato A, Miura T |
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Address
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Kobe Women's College of Pharmacy, Japan |
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Abstract
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The hypoglycemic effect of the rhizomes
of Polygonatum officinale (Liliaceae) was investigated in both normal
and streptozotocin-induced diabetic mice. The methanol extract of
rhizomes of Polygonatum officinale (PO) (800 mg/kg) reduced the blood
glucose of normal mice from 170 +/- 3 to 136 +/- 5 mg/100 ml 4 hours
after intraperitoneal administration (P < 0.001), and also
significantly lowered the blood glucose of streptozotocin-induced
diabetic mice from 696 +/- 60 to 407 +/- 35 mg/100 ml under similar
conditions (P < 0.01). PO also suppressed epinephrine-induced
hyperglycemia in mice. In addition, the n-butanol fraction of the
methanol extract elicited a significant decrease in the blood glucose
level of streptozotocin-induced diabetic mice after 4 hours (P <
0.05). |
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Diseases |
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Disease Link |
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