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DiaMedBase ID |
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DMPPg543 |
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Medicinal Plant
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Cucurbita ficifolia, Phaseolus
vulgaris, Opuntia streptacantha, Spinacea oleracea, Cucumis sativus,
Cuminum cyminum,
Brassica oleracea var. botrytis, Allium cepa, Allium sativum,
Psidium guajava, Brassica oleracea and Lactuca sativa var. romana |
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Plant part(s)
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Whole plant |
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Objective |
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To study the anti-hyperglycemic effect of 12 edible
plants |
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Journal Source
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Journal of Ethnopharmacology
1995; 48:25-32 |
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Title
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Anti-hyperglycemic effect of some edible plants |
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Authors
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R. Roman-Ramos, J.L. Flores-Saenz, F.J. Alarcon-Aguilar |
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Address
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Department of Health Sciences, Division of Biological
and Health Sciences, Metropolitan Autonomous University, lztapalapa
Campus. Mexico, D.F., Apdo. Postal 55-535, Mexico |
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Abstract
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The anti-hyperglycemic effect of
12 edible plants was studied on 27 healthy rabbits, submitted weekly
to subcutaneous glucose tolerance tests after gastric administration
of water, tolbutamide or a traditional preparation of the plant.
Tolbutamide, Cucurbita ficifolia, Phaseolus vulgaris, Opuntia
streptacantha, Spinacea oleracea, Cucumis sativus and Cuminum
cyminum decrease significantly the area under the glucose
tolerance curve and the hyperglycemic peak.
Brassica oleracea
var. botrytis, Allium cepa and Allium sativum
only decrease the hyperglycemic peak. The glycemic decreases
caused by Psidium guajava, Brassica oleracea and Lactuca
sativa var. romana were not significant (p > 0.05). The
integration of a menu that includes the edible plants with
hypoglycemic activity for the control and prevention of diabetes
mellitus may be possible and recommendable. |
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Diseases |
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Disease Link |
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DiaMedBase ID |
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DMPPg544 |
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Medicinal Plant
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Psidium guajava |
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Plant part(s)
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Leaves |
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Objective |
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To exhibit
significant inhibitory effect on PTP1B |
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Journal Source
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J Ethnopharmacol,
2005; 96(3):411-415 |
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Title
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Antidiabetic effects of extracts from Psidium guajava |
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Authors
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Oh WK, Lee CH, Lee
MS, Bae EY, Sohn CB, Oh H, Kim BY, Ahn JS |
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Address
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Korea Research
Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115,
Yusong, Daejeon 305-600, South Korea |
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Abstract
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During a screening of medicinal plants
for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract
from Psidium guajava (Myrtaceae) leaves exhibited significant
inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr(db)/Lepr(db)
mice was evaluated. Significant blood glucose lowering effects of the
extract were observed after intraperitoneal injection of the extract
at a dose of 10mg/kg in both 1- and 3-month-old Lepr(db)/Lepr(db)
mice. In addition, histological analysis of the liver from the butanol-soluble
fraction treated Lepr(db)/Lepr(db) mice revealed a significant
decrease in the number of lipid droplets compared to the control mice.
Taken together, it was suggested that the extract from Psidium guajava
leaves possesses antidiabetic effect in type 2 diabetic mice model and
these effect is, at least in part, mediated via the inhibition of
PTP1B. |
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Diseases |
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Disease Link |
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