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DiaMedBase ID
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DMPPc545 |
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Medicinal Plant
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Psoralea corylifolia |
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Plant part(s)
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Seeds |
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Objective
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To study Protein tyrosine phosphatase
1B which plays a major role in the negative regulation of insulin
signaling |
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Journal Source
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Planta Med. 2005; 71(1):87-89 |
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Title
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In vitro protein tyrosine
phosphatase 1B inhibitory phenols from the seeds of Psoralea
corylifolia |
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Authors
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Kim YC, Oh H, Kim BS, Kang TH, Ko EK,
Han YM, Kim BY, Ahn JS |
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Address
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Phytofermentation Research Center and
College of Pharmacy, Wonkwang University, Iksan, South Korea |
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Abstract
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Protein tyrosine phosphatase 1B plays a
major role in the negative regulation of insulin signaling, and this
establishes protein tyrosine phosphatase 1B as an attractive
therapeutic target for diabetes. Bioassay-guided fractionation of the
EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded
two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin
(1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2
inhibited PTP1B activity in a dose-dependent manner, displaying IC50
values of 9.4 +/- 0.5 microM and 20.8 +/- 1.9 microM, respectively. |
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Diseases |
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Disease Link |
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