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DiaMedBase ID |
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DMPPa557 |
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Medicinal Plant
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Pycnanthus angolensis
Warb |
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Plant part(s)
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Leaves and stems |
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Objective |
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To study the
effects of pycanthuquinone A and pycanthuquinone B on the diabetic
mouse |
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Journal Source
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J Org Chem,
2000; 65(20):6534-6539 |
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Title
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Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis |
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Authors
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Fort DM, Ubillas
RP, Mendez CD, Jolad SD, Inman WD, Carney JR, Chen JL, Ianiro TT,
Hasbun C, Bruening RC, Luo J, Reed MJ, Iwu M, Carlson TJ, King SR,
Bierer DE, Cooper R |
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Address
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Shaman
Pharmaceuticals Inc., South San Francisco, California 94080-4812, USA.
dfort@pharmanex.com |
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Abstract
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Two new compounds,
pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from
leaves and stems of the African plant, Pycnanthus angolensis (Welw.)
Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic
extract using a diabetic mouse model. Pycnanthuquinones A and B are
the first representatives of a novel terpenoid-type quinone skeleton,
and both compounds possess significant antihyperglycemic activity. |
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Diseases |
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Disease Link |
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